{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:20:18Z","timestamp":1771492818531,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of gender in Achilles tendinopathy is yet to be determined. We hypothesized that female patients respond the same as males to 12 weeks of painful eccentric training. A total number of 75 consecutive mid\u2010portion patients with Achilles tendinopathy (25 females, 38\u00a0males) were enrolled in a cohort study with 63 being analyzed after 12 weeks according to their gender for tendon and paratendon microcirculatory mapping. Outcome was determined by pain on visual analogue scale, VISA\u2010A score, Foot Ankle Outcome Score (FAOS), tendon and paratendon capillary blood flow, oxygen saturation, and postcapillary venous filling pressures. Eccentric training resulted in a morning resting pain reduction by 44% in males (<jats:italic>P<\/jats:italic> = 0.001) and by 27% in females (<jats:italic>P<\/jats:italic> = 0.08). VISA\u2010A score improved in males by 27% from 63 \u00b1 12 to 86 \u00b1 13 (<jats:italic>P<\/jats:italic> = 0.036) and by 20% in females from 60 \u00b1 14 to 75 \u00b1 11 (<jats:italic>P<\/jats:italic> = 0.043, <jats:italic>P<\/jats:italic> &lt; 0.05 for gender difference). Among females, only one out of five FAOS items was increased (sport 72 \u00b1 21 to 82 \u00b1 15, <jats:italic>P<\/jats:italic> = 0.045), while in males, four out of five items were increased (symptoms, pain, all\u2010day\u2010life, and sport, all <jats:italic>P<\/jats:italic> &lt; 0.01). The microcirculatory gender\u2010specific response to eccentric training revealed a greater postcapillary venous filling pressure reduction among symptomatic females and inconclusive capillary blood flow changes. No change in tendon oxygenation was noted in both genders. Symptomatic females suffering Achilles tendinopathy do not benefit as much as symptomatic males from 12 weeks of eccentric training. The pain reduction is significantly lower among symptomatic females in contrast to males, and the improvement in the FAOS and VISA\u2010A scores is significantly lower among females in contrast to males. Additional treatment options warrant scrutiny to symptomatic females suffering Achilles tendinopathy beyond eccentric training.<\/jats:p>","DOI":"10.1007\/s00167-009-1006-7","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T13:42:24Z","timestamp":1260279744000},"page":"648-655","source":"Crossref","is-referenced-by-count":30,"title":["Gender and eccentric training in Achilles mid\u2010portion tendinopathy"],"prefix":"10.1002","volume":"18","author":[{"given":"Karsten","family":"Knobloch","sequence":"first","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Schreibmueller","sequence":"additional","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jagodzinski","sequence":"additional","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Redeker","sequence":"additional","affiliation":[{"name":"Plastic Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465980260030301"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2007.035543"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2006.00543.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010003\u20100418\u2010z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507309674"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31819794c3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070602701115"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"JonssonP AlfredsonH SundingKet al. 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