{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:48:39Z","timestamp":1793810919026,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T00:00:00Z","timestamp":1282780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Platelet\u2010rich plasma (PRP) therapy is a simple, low\u2010cost and minimally invasive method that provides a natural concentrate of autologous blood growth factors (GFs) that can be used to enhance tissue regeneration. In a previous analysis of a 12\u2010month follow\u2010up study, promising results were obtained when treating patients affected by knee degeneration with PRP intra\u2010articular injections. The main purpose of this study was to investigate the persistence of the beneficial effects observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of the 91 patients evaluated in the previous 12\u2010month follow\u2010up study, 90 were available for the 2\u2010year follow\u2010up (24 patients presented a bilateral lesion, in a total of 114\u00a0knees treated). All of the patients presented a chronic knee degenerative condition and were treated with three intra\u2010articular PRP injections. IKDC and EQ\u2010VAS scores were used for clinical evaluation. Complications, adverse events and patient satisfaction were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the evaluated parameters worsened at the 24\u2010month follow\u2010up: these parameters were at significantly lower levels with respect to the 12\u2010month evaluation (the IKDC objective evaluation fell from 67 to 59% of normal and nearly normal knees; the IKDC subjective score fell from 60 to 51), even if they remained higher than the basal level. Further analysis showed better results in younger patients (<jats:italic>P<\/jats:italic> = 0.0001) and lower degrees of cartilage degeneration (<jats:italic>P<\/jats:italic> &lt; 0.0005). The median duration of the clinical improvement was 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicate that treatment with PRP injections can reduce pain and improve knee function and quality of life with short\u2010term efficacy. Further studies are needed to confirm these results and understand the mechanism of action, and to find other application modalities, with different platelet and GF concentrations and injection timing, which provide better and more durable results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-010-1238-6","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T11:30:32Z","timestamp":1282735832000},"page":"528-535","source":"Crossref","is-referenced-by-count":327,"title":["Platelet\u2010rich plasma intra\u2010articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis"],"prefix":"10.1002","volume":"19","author":[{"given":"Giuseppe","family":"Filardo","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Biomechanics Laboratory\u2014III Clinic Rizzoli Orthopaedic Institute Via Di Barbiano 1\/10 40136 Bologna 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