{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:25:21Z","timestamp":1789921521474,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T00:00:00Z","timestamp":1297814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG\u2010250191"],"award-info":[{"award-number":["CMRPG\u2010250191"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG\u2010270291"],"award-info":[{"award-number":["CMRPG\u2010270291"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The fixation and incorporation of ruptured rotator cuff tendon to bone is a major concern in rotator cuff repair surgery. Rotator cuff repair usually fails at the tendon\u2013bone interface, especially in case of large or massive tears. To enhance tendon\u2013bone healing, an injectable hydrogel made with periosteal progenitor cells(PPCs) and poly (ethylene glycol) diacrylate (PEGDA) tethered with bone morphogenic protein\u20102(BMP\u20102) was developed to encourage extracellular matrix synthesis for tendon\u2010to\u2010bone healing in rotator cuff repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The infraspinatus tendon was cut from the greater tuberosity and repaired through a transosseous tunnel with the injectable progenitor cell\u2010BMP\u20102 hydrogel applied between the tendon\u2013bone interface. The injectable hydrogel was prepared from 10% poly (ethylene glycol) diacrylate (PEGDA) containing 0.05% of the photoinitiator. BMP\u20102 tethered with poly(ethylene glycol) (PEG) was blended to the hydrogel. Rabbit periosteal progenitor cells (PPCs) isolated from periosteum were mixed with hydrogel and injected on the tendon\u2013bone interface. Ultraviolet radiation (365\u00a0nm) was applied for 60 s to photopolymerize the injection and solidify the hydrogel. The rabbits were killed at 4 and 8 weeks. The morphological characteristics of the healing tendon\u2010to\u2010bone interface were evaluated by histological and immunohistochemical methods. The biomechanical test was done to determine healing attachment strength.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At both the 4\u2010 and 8\u2010week killing, histological analysis of the tendon\u2013bone interface showed an increasing fibrocartilage and bone layer formed in the tendon\u2013bone interface in PEGDA group. At 4 weeks, fibrocartilage\u2010like tissue was observed in a focal area. At 8 weeks, further matrix deposition occurred with fibrocartilage formation in the tendon\u2013bone junction, and bone formation appeared near host bone. Immunohistochemistry revealed the presence of aggrecan and type II collagen. Biomechanical testing revealed a higher maximum pull\u2010out load at all time points with a statistically significant difference at 4 and 8 weeks postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PEGDA hydrogel was approved as an adequate matrix for the encapsulation of cells and signal factor, and as an effective local delivery method to the tendon\u2013bone interface through injection and photopolymerization. The PPCs\u2010BMP2\u2010hydrogel provides a powerful inductive ability between the tendon and the bone and enhances tendon\u2013bone healing through the neoformation of fibrocartilage.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-010-1373-0","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T08:46:08Z","timestamp":1297759568000},"page":"1597-1607","source":"Crossref","is-referenced-by-count":77,"title":["Enhancement of rotator cuff tendon\u2013bone healing with injectable periosteum progenitor cells\u2010BMP\u20102 hydrogel in vivo"],"prefix":"10.1002","volume":"19","author":[{"given":"Chih\u2010Hwa","family":"Chen","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Surgery, Chang Gung Memorial Hospital\u2010Keelung Chang Gung University, College of Medicine Taoyuan 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