{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:20:24Z","timestamp":1780478424719,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Rupture of the anterior cruciate ligament is common and may necessitate surgical reconstruction. Surgical reconstruction aims to restore normal kinematics and biology within the knee. The acute phase response after surgical reconstruction remains poorly defined but may influence graft integration through modulation of host tissue remodelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The very early host production of key cytokines after surgery was studied. A consecutive series of 14 patients undergoing reconstructive surgery were studied per\u2010operatively, 1 and 6 h after surgery, examining the hypothesis that the acute phase response would be non\u2010specific but consistent between individuals, demonstrating increases of pro\u2010inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A consistent increased release of monocyte\u2010driven, non\u2010specific, IL\u20101 and IL\u20106 release but not T cell\u2010derived IL\u20102 was found. Perhaps, more interestingly, very early high concentrations of secondary growth factors PDGF and TGF\u2010\u03b2 suggestive of an anabolic response were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data support the contention that an anabolic response starts earlier than previously thought within the surgically reconstructed knee.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-011-1486-0","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T04:37:09Z","timestamp":1301287029000},"page":"1709-1715","source":"Crossref","is-referenced-by-count":28,"title":["Analysis of sequential cytokine release after ACL reconstruction"],"prefix":"10.1002","volume":"19","author":[{"given":"A. 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