{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:20:04Z","timestamp":1777710004055,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T00:00:00Z","timestamp":1311120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen consecutive patients (9 women, 5\u00a0men, mean age of 59.2 years) with complete rotator cuff tears (mean preoperative UCLA score of 12 \u00b1 3.0) were fixed by transosseous stitches through mini\u2010open incision, with subsequent injection of BMMC into the tendon borders, obtained from the iliac crest just prior to surgery. Magnetic resonance images (MRI) were acquired before and after surgery and evaluated by two musculoskeletal radiologists regarding new postoperative findings of patients treated with BMMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a minimum 12\u2010month follow\u2010up period, the UCLA score increased from 12 \u00b1 3.0 to 31 \u00b1 3.2. Clinical findings remained unaltered in the following year in all but one patient (13\/14). MRI analysis after a 12\u2010month follow\u2010up period demonstrated tendon integrity in all cases (14\/14), presence of low\u2010signal intensity areas along the supraspinatus tendon and distal muscle belly in 8 cases (8\/14), and high\u2010intensity blooming small round artifact at the bursal and tendon topography in 11 cases (11\/14). Six patients (6\/14) showed formation of a high\u2010signal intensity zone at the critical zone. Clinical findings remained unaltered in the following year in all but one patient, who relapsed into loss of strength and pain, being considered a bad result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implantation of BMMC in rotator cuff sutures appears to be a safe and promising alternative to other biological approaches currently used to enhance tissue quality in affected tendons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-011-1607-9","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T10:47:04Z","timestamp":1311072424000},"page":"373-377","source":"Crossref","is-referenced-by-count":203,"title":["Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Jo\u00e3o L.","family":"Ellera Gomes","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Faculdade de Medicina Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"<!--<label>2<\/label>--> Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Porto Alegre Brazil"},{"name":"<!--<label>4<\/label>--> Rua Des. Moreno Loureiro Lima 195\/901 90450\u2010130 Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Canquerini","family":"da Silva","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia M. R.","family":"Silla","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Faculdade de Medicina Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"<!--<label>2<\/label>--> Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo R.","family":"Abreu","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Hospital M\u00e3e de Deus Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pellanda","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Faculdade de Medicina Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"<!--<label>2<\/label>--> Hospital de Cl\u00ednicas de Porto Alegre (HCPA) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.12.009"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199274100-00009"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00813"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.12.012"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/BTE.0b013e3181b22e65"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1198"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010009\u20100809\u2010x"},{"key":"e_1_2_7_9_2","first-page":"3","article-title":"Rupture of the supraspinatus tendon. 1911","volume":"254","author":"Codman EA","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mse.2003.21"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.09.027"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010001\u20100263\u2010x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1528"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.7547\/0980466"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200402000-00002"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200004000-00006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0210"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354659402200214"},{"issue":"1","key":"e_1_2_7_19_2","first-page":"126","article-title":"L\u2019\u00e9valuation par le scanner de la trophicit\u00e9 des muscles de la coiffe des rotateurs ayant une rupture tendineuse","volume":"75","author":"Goutallier D","year":"1989","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.87B2.15305"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.1.4.563"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.09.007"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749\u20108063(03)00169\u20105"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.06.017"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010008\u20100646\u20103"},{"key":"e_1_2_7_26_2","first-page":"87","article-title":"Failed repair of the rotator cuff: evaluation and treatment of complications","volume":"47","author":"Karas EH","year":"1998","journal-title":"Instr Course Lect"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010007\u20100112\u20104"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.81B2.9154"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2004.02.016"},{"key":"e_1_2_7_30_2","first-page":"1349","article-title":"Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow","volume":"22","author":"Liu H","year":"2008","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"e_1_2_7_31_2","first-page":"223","article-title":"The cascade membrane: a new PRP device for tendon ruptures. 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