{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:45:14Z","timestamp":1792881914187,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T00:00:00Z","timestamp":1320710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With the emerging interest in regenerative medicine and tissue engineering, new treatment modalities being developed for joint disorders including joint surface lesions and articular cartilage defects. The clinical outcome of these novel approaches appears rather unpredictable and is due to many reasons but definitely also linked to the patient profile. As a typical example, symptomatic articular cartilage lesions can be presented in an otherwise normal joint, or associated with several other joint tissue alterations including meniscal lesions and abnormalities of the underlying bone. The outcome of novel treatments may well be influenced by the status of the whole joint, and the potential to develop osteoarthritis. To better identify the patients at risk and responders to certain treatments, it is of use to define and most importantly classify patients with \u201cearly osteoarthritis\u201d. Here, classification criteria for this group of patients are presented, allowing a more defined and accurate inclusion in clinical trials in the future.<\/jats:p>","DOI":"10.1007\/s00167-011-1743-2","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T05:22:49Z","timestamp":1320643369000},"page":"401-406","source":"Crossref","is-referenced-by-count":243,"title":["Definition and classification of early osteoarthritis of the knee"],"prefix":"10.1002","volume":"20","author":[{"given":"Frank P.","family":"Luyten","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders Katholieke Universiteit Leuven O&amp;N 1, Herestraat 49, Bus 813 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Denti","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Knee Surgery and Sports Traumatology, IRCCS Istituto Clinico Humanitas Via Manzoni 56 Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Filardo","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute Via di Barbiano 1\/10 40136 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Kon","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute Via di Barbiano 1\/10 40136 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Engebretsen","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Department of Sports Medicine, Oslo Sports Trauma Research Center Norwegian School of Sport Sciences 608 Oslo Norway"},{"name":"<!--<label>5<\/label>--> Department of Orthopaedic Surgery University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510373917"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.06.016"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.155119"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066183"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.10.027"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010009\u20100940\u20108"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.017"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510373876"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1999.29.7.400"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350694"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507311095"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3052"},{"key":"e_1_2_7_18_2","unstructured":"The European Parliament and the Council of the European Union(2007)Regulation (EC) No.1394\/2007 of the European Parliament and of the Council of 13 November 2007 on advances therapy medicinal products and amending directive 2001\/83\/EC and regulation (EC) No 726\/2004. 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