{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:27:17Z","timestamp":1760920037199,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>A male patient suffering from non\u2010union of the femoral diaphysis after a traumatic fracture was treated with deep decortication and grafted with lyophilized bone, platelet gel (PG) and autologous bone marrow stromal cells (BMSCs). After 40\u00a0days from surgery, he was re\u2010operated, due to fracture secondary displacement, caused by inappropriate load during sports activity. In addition to radiographs, two bone biopsies were retrieved: this allowed for a histological evaluation of the early response of host bone to the graft. To our knowledge, there is no report describing such early tissue response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical\u2010radiographic evaluation of the patient and a histomorphometric analysis of the bone biopsies were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An early reparative bone formation was observed adjacent to the osteointegrated graft. Non\u2010resorbed bone chips and large islands of non\u2010vital bone particles, surrounded by fibrous tissue, were observed in a zone of sclerotic diaphyseal bone, that is the process was delayed despite decortication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings support the concept, until now evidenced only by imaging, that bone chips added with PG and BMSCs are effective in shortening the healing time in fracture non\u2010union. The clinical relevance of deep decortication and vascularization is emphasized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Therapeutic studies\u2014investigating the results of treatment, Level V.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-011-1790-8","type":"journal-article","created":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T00:57:14Z","timestamp":1322009834000},"page":"1834-1838","source":"Crossref","is-referenced-by-count":1,"title":["Relevance of deep decortication and vascularization in a case of post\u2010traumatic femoral non\u2010union treated with grafts, platelet gel and bone marrow stromal cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Dante","family":"Dallari","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Orthopaedic and Traumathological Department I Istituto Ortopedico Rizzoli Via di Barbiano 1\/10 40136 Bologna 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Del","family":"Piccolo","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Orthopaedic and Traumathological Department I Istituto Ortopedico Rizzoli Via di Barbiano 1\/10 40136 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Baldini","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine Istituto Ortopedico Rizzoli Via di Barbiano 1\/10 40136 Bologna 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