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While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an\n                    <jats:italic>unfavorable biomechanical environment<\/jats:italic>\n                    at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Level of evidence<\/jats:italic>\n                    IV.\n                  <\/jats:p>","DOI":"10.1007\/s00167-011-1818-0","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:48:56Z","timestamp":1323910136000},"page":"423-435","source":"Crossref","is-referenced-by-count":306,"title":["Biomechanical considerations in the pathogenesis of osteoarthritis of the knee"],"prefix":"10.1002","volume":"20","author":[{"given":"Andras","family":"Heijink","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Surgery Academic Medical Center (AMC) Meibergdreef 9 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H.","family":"Gomoll","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Orthopaedic Surgery, Brigham and Women\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Madry","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Experimental Orthopaedics and Osteoarthritis Research and Department of Orthopaedic Surgery Saarland University Medical Center Homburg\/Saar Germany"},{"name":"<!--<label>4<\/label>--> Saarland University Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Drobni\u010d","sequence":"additional","affiliation":[{"name":"<!--<label>5<\/label>--> Department of Orthopaedic Surgery University Medical Center Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Filardo","sequence":"additional","affiliation":[{"name":"<!--<label>6<\/label>--> III Clinic, Biomechanics Laboratory Rizzoli Orthopedic Institute Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Espregueira\u2010Mendes","sequence":"additional","affiliation":[{"name":"<!--<label>7<\/label>--> Cl\u00ednica Sa\u00fade Atl\u00e2ntica Minho and Porto Universities Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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