{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:14:45Z","timestamp":1786979685657,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the long\u2010term outcome and prosthetic survival of primary total knee arthroplasty in haemophilic patients. It was hypothesized that the infection and revision rate are higher and the outcome inferior when compared with patients without haemophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 1985 and 2004, forty\u2010three consecutive primary total knee replacements were performed in thirty haemophilic patients. These patients\u2019 charts were reviewed retrospectively. Twenty\u2010five patients (34\u00a0knees) were available for clinical and radiological follow\u2010up. The outcome was assessed using the Knee Society score, WOMAC and Kaplan\u2013Meier survivorship analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An haematogenous infection occurred in two patients. In three patients, component revision was needed: two because of an infection and one because of a mechanical failure. After a mean follow\u2010up of 9.6 years (2\u201320), 94% of the patients rated their result as either excellent or good. At time of follow\u2010up, the Knee Society Score averaged 73.3 points (range, 29\u2013100) and showed a significant gain (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) compared to preoperative. Flexion contracture could be reduced significantly (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) from 18.1\u00b0 preoperatively to 8.4\u00b0 at follow\u2010up, whereas flexion remained unchanged. When infection or any component replacement was set as endpoints, the 10 years prosthetic survival was 90 and 86%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Total knee arthroplasty in haemophilic patients is a reliable treatment that results in pain relief and functional improvement with a low risk of postoperative infection. However, neither the postoperative infection rate nor the functional result does reach the same level as in a population not affected by haemophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-012-1896-7","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T01:29:14Z","timestamp":1327973354000},"page":"2465-2470","source":"Crossref","is-referenced-by-count":42,"title":["Haemophilic knee arthropathy: long\u2010term outcome after total knee replacement"],"prefix":"10.1002","volume":"20","author":[{"given":"Patrick O.","family":"Zingg","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Division of Knee Surgery, Department of Orthopaedics University of Zurich Balgrist Forchstrasse 340 8008 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro F.","family":"Fucentese","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Division of Knee Surgery, Department of Orthopaedics University of Zurich Balgrist Forchstrasse 340 8008 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Lutz","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Raemistrasse 100 8091 Zurich Switzerland"},{"name":"<!--<label>3<\/label>--> Department of Haematology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigit","family":"Brand","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Raemistrasse 100 8091 Zurich Switzerland"},{"name":"<!--<label>3<\/label>--> Department of Haematology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Mamisch","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Raemistrasse 100 8091 Zurich Switzerland"},{"name":"<!--<label>4<\/label>--> Department of Radiocopy University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Koch","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Division of Knee Surgery, Department of Orthopaedics University of Zurich Balgrist Forchstrasse 340 8008 Z\u00fcrich 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