{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:48:10Z","timestamp":1782218890255,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T00:00:00Z","timestamp":1327708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Treatment of large cartilage lesions of the knee in weight\u2010bearing areas is still a controversy and challenging topic. Autologous osteochondral mosaicplasty has proven to be a valid option for treatment but donor site morbidity with most frequently used autografts remains a source of concern. This study aims to assess clinical results and safety profile of autologous osteochondral graft from the upper tibio\u2010fibular joint applied to reconstruct symptomatic osteochondral lesions of the knee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients (22\u00a0men and 9 women) with grade 4 cartilage lesions in the knee were operated by mosaicplasty technique using autologous osteochondral graft from the upper tibio\u2010fibular joint, between 1998 and 2006. Clinical assessment included visual analog scale (VAS) for pain and Lysholm score. All patients were evaluated by MRI pre\u2010 and <jats:italic>post<\/jats:italic>\u2010operatively regarding joint congruency as good, fair (inferior to 1\u00a0mm incongruence), and poor (incongruence higher than 1\u00a0mm registered in any frame). Donor zone status was evaluated according to specific protocol considering upper tibio\u2010fibular joint instability, pain, neurological complications, lateral collateral ligament insufficiency, or ankle complaints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age at surgery was 30.1 years (SD 12.2). In respect to lesion sites, 22 were located in weight\u2010bearing area of medial femoral condyle, 7\u00a0in lateral femoral condyle, 1\u00a0in trochlea, and 1\u00a0in patella. Mean follow\u2010up was 110.1\u00a0months (SD 23.2). Mean area of lesion was 3.3\u00a0cm<jats:sup>2<\/jats:sup> (SD 1.7), and a variable number of cylinders were used, mean 2.5 (SD 1.3). Mean VAS score improved from 47.1 (SD 10.1) to 20.0 (SD 11.5); <jats:italic>p<\/jats:italic> = 0.00. Similarly, mean Lysholm score increased from 45.7 (SD 4.5) to 85.3 (SD 7.0); <jats:italic>p<\/jats:italic> = 0.00. The level of patient satisfaction was evaluated, and 28 patients declared to be satisfied\/very satisfied and would do surgery again, while 3 declared as unsatisfied with the procedure and would not submit to surgery again. These three patients had lower clinical scores and kept complaints related to the original problem but unrelated to donor zone. MRI score significantly improved at 18\u201324\u00a0months comparing with pre\u2010operative (<jats:italic>p<\/jats:italic> = 0.004). No radiographic or clinical complications related to donor zone with implication in activity were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This work corroborates that mosaicplasty technique using autologous osteochondral graft from the upper tibio\u2010fibular joint is effective to treat osteochondral defects in the knee joint. No relevant complications related to donor zone were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Case series, Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-012-1910-0","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T03:37:28Z","timestamp":1327635448000},"page":"1136-1142","source":"Crossref","is-referenced-by-count":38,"title":["Osteochondral transplantation using autografts from the upper tibio\u2010fibular joint for the treatment of knee cartilage lesions"],"prefix":"10.1002","volume":"20","author":[{"given":"Jo\u00e3o","family":"Espregueira\u2010Mendes","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"},{"name":"<!--<label>2<\/label>--> 3B\u2019s Research Group\u2010Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, S. Cl\u00e1udio de Barco 4806\u2010909 Taipas Guimar\u00e3es Portugal"},{"name":"<!--<label>3<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga Guimar\u00e3es Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lder","family":"Pereira","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"},{"name":"<!--<label>2<\/label>--> 3B\u2019s Research Group\u2010Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, S. Cl\u00e1udio de Barco 4806\u2010909 Taipas Guimar\u00e3es Portugal"},{"name":"<!--<label>3<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga Guimar\u00e3es Portugal"},{"name":"<!--<label>4<\/label>--> Orthopedic Department Centro Hospitalar P\u00f3voa de Varzim Vila do Conde Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Sevivas","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"},{"name":"<!--<label>3<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga Guimar\u00e3es Portugal"},{"name":"<!--<label>5<\/label>--> Orthopedic Department Hospital de Braga Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Varanda","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"},{"name":"<!--<label>3<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga Guimar\u00e3es Portugal"},{"name":"<!--<label>5<\/label>--> Orthopedic Department Hospital de Braga Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Vieira","family":"da Silva","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"},{"name":"<!--<label>3<\/label>--> ICVS\/3B\u2019s\u2010PT Government Associate Laboratory Braga Guimar\u00e3es Portugal"},{"name":"<!--<label>5<\/label>--> Orthopedic Department Hospital de Braga Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Monteiro","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sa\u00fade Atl\u00e2ntica Sports Center\u2013F.C. Porto Stadium Minho University and Porto University Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> 3B\u2019s Research Group\u2010Biomaterials, Biodegradables and Biomimetics University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, S. 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