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Subsequently, thousands of studies have been published that greatly improved our understanding of the aetiology, surgical reconstruction techniques and prevention of anterior cruciate ligament (ACL) injuries. The purpose of this review is to summarize the evidence from biomechanical studies on ACL\u2010related research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010impact articles that enhanced understanding of ACL injury aetiology, rehabilitation, prevention and adaptations after reconstruction were selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The importance of restoring internal tibial rotation after ACL reconstruction has emerged in several studies. Criteria\u2010based, individualized rehabilitation protocols have replaced the traditional time\u2010based protocols. Excessive knee valgus, poor trunk control, excessive quadriceps forces and leg asymmetries have been identified as potential high risk biomechanical factors for ACL tear. Injury prevention programmes have emerged as low cost and effective means of preventing ACL injuries, particularly in female athletes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a result of biomechanical research, clinicians have a better understanding of ACL injury aetiology, prevention and rehabilitation. Athletes exhibiting neuromuscular deficits predisposing them to ACL injury can be identified and enrolled into prevention programmes. Clinicians should assess ACL\u2010reconstructed patients for excessive internal tibial rotation that may lead to poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-012-1955-0","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:54:39Z","timestamp":1332464079000},"page":"755-766","source":"Crossref","is-referenced-by-count":37,"title":["Lessons learned from the last 20 years of ACL\u2010related in vivo\u2010biomechanics research of the knee joint"],"prefix":"10.1002","volume":"21","author":[{"given":"Evangelos","family":"Pappas","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Division of Physical Therapy Long Island University\u2010Brooklyn Campus 11201 Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franceska","family":"Zampeli","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> 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