{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:55:04Z","timestamp":1790254504695,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:00:00Z","timestamp":1332460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Surgery involving arthroscopic reconstruction of the injured ligament is the gold standard treatment for torn anterior cruciate ligament (ACL). Recent studies support the hypothesis of biological self\u2010healing of ruptured ACL. The aim of the study is to evaluate, in an animal model, the efficacy of a new technique, dynamic intraligamentary stabilization that utilizes biological self\u2010healing for repair of acute ACL ruptures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ACL in 11 adult female white alpine sheep was transected and in 8 sheep reconstructed by dynamic intraligamentary stabilization. To enhance the healing potential, microfracturing and collagen were used in all animals. The contralateral, non\u2010operated knees served as controls. At 3\u00a0months postkilling, all animals were submitted to magnetic resonance imaging and biomechanical and histological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No surgery\u2010related complications were observed. Postoperatively, all animals regularly used the operated leg with full weight bearing and no lameness. At the time of killing, all animals exhibited radiological and histological healing of the transacted ACL. Biomechanical tests confirmed successful restoration of anteroposterior translation in the dynamic intraligamentary stabilization knees. Histological examination revealed dense scar tissue at the ends of the transected ligaments exhibiting hypercellularity and hypervascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The dynamic intraligamentary stabilization technique successfully induced self\u2010healing of ruptured ACL in a sheep model. Knee joints remained stable during the healing period allowing free range of motion and full weight bearing, and no signs of osteoarthritis or other intraarticular damage in the follow up were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-012-1958-x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:59:28Z","timestamp":1332464368000},"page":"599-605","source":"Crossref","is-referenced-by-count":57,"title":["Anterior crucial ligament rupture: self\u2010healing through dynamic intraligamentary stabilization technique"],"prefix":"10.1002","volume":"21","author":[{"given":"Sandro","family":"Kohl","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios S.","family":"Evangelopoulos","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Kohlhof","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Hartel","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Bonel","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Radiology, Inselspital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Henle","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"von Rechenberg","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Equine Hospital, Vetsuisse Faculty University of Z\u00fcrich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eggli","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopedic Surgery, Inselspital University of Bern Freiburgstrasse 3010 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736\u20100266(02)00265\u20106"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200410000-00004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010010\u20101077\u20104"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100010305"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199506000-00008"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38784.384109.2F"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014455"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510395477"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.08.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736\u20100266(02)00033\u20105"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679008993504"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20981"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT\u201010\u201001\u20100012"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01158"},{"key":"e_1_2_6_16_2","first-page":"768","article-title":"Resection of the anterior cruciate ligament of the knee using arthroscopy induces arthrosis in dogs. 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