{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:45:49Z","timestamp":1779194749350,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:00:00Z","timestamp":1347667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to assess inflammation and the presence and relative levels of cytokines, which may be involved in regulating early human Achilles tendon healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with acute Achilles tendon rupture were included, operated on and post\u2010operatively immobilized. Two weeks post\u2010operatively, microdialysis of the peritendinous interstitial compartment was performed in the healing and intact contralateral Achilles tendons. Quantification of tumour necrosis factor (TNF)\u2010\u03b1, interferon (IFN)\u2010\u03b3, interleukin (IL)\u20101\u03b2, IL\u20106, IL\u20108, IL\u201010, IL\u201012p70 and IL\u201017A was accomplished using a cytometric bead array. Prostaglandin (PG) E<jats:sub>2<\/jats:sub> levels were measured by enzyme immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the patients displayed detectable PGE<jats:sub>2<\/jats:sub> levels. Pro\u2010inflammatory cytokines were below detection levels (IFN\u03b3, IL\u201012, and IL\u201017) or did not differ between injured and control tendons (IL\u20101\u03b2 and TNF). Notably, IL\u20106, IL\u20108 and IL\u201010 concentrations in the healing Achilles tendon were significantly elevated: 13\u2010fold (<jats:italic>p<\/jats:italic> = 0.009), 28\u2010fold (<jats:italic>p<\/jats:italic> = 0.02), and 3.7\u2010fold (<jats:italic>p<\/jats:italic> = 0.03), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 2 weeks post\u2013human Achilles tendon rupture, healing is characterized by a resolving inflammatory phase and up\u2010regulation of IL\u20106, IL\u20108 and IL\u201010. The absence of inflammation suggests that at this time point, these cytokines may be associated with anti\u2010inflammatory and regenerative effects on the tendon healing process.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-012-2197-x","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T23:00:48Z","timestamp":1347663648000},"page":"1801-1806","source":"Crossref","is-referenced-by-count":66,"title":["Anti\u2010inflammatory cytokine profile in early human tendon repair"],"prefix":"10.1002","volume":"21","author":[{"given":"P. W.","family":"Ackermann","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"},{"name":"<!--<label>3<\/label>--> Department of Orthopedic Karolinska University Hospital 171 76 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Domeij\u2010Arverud","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Leclerc","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Medicine, Center of Molecular Medicine (CMM) Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Amoudrouz","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Medicine, Center of Molecular Medicine (CMM) Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Nader","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Medicine, Center of Molecular Medicine (CMM) Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"17","volume-title":"Achilles tendon rupture. 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