{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:21:09Z","timestamp":1790083269725,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Intraoperative local infiltration analgesia has gained increasing popularity in joint replacement surgery. Because there is considerable variation among drug combinations, analgesic effects of each drug are not well understood. The purpose of this study was to clarify the efficacy of the addition of steroid to local anaesthetics in local infiltration analgesia during total knee arthroplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients were randomly allocated to the steroid or control group. Patients in the steroid group received peri\u2010articular injection of ropivacaine, dexamethasone and isepamicin, while dexamethasone was omitted from the analgesic mixture in the control group. Primary outcome was pain severity at rest using 100\u00a0mm visual analogue scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain severity in the steroid group was lower than control group and there were significant differences between groups at post\u2010operative day 1 and 3. Reduction in post\u2010operative pain was associated with a decrease in serum C\u2010reactive protein and interleukin 6\u00a0in drainage fluid. The number of patients who were able to perform straight leg raise within post\u2010operative day 2 was 15\/20\u00a0in the steroid group, which was significantly higher than the control group 5\/20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding steroid to local anaesthetics in local infiltration analgesia reduced inflammation both locally and systemically, resulting in significant early pain relief and rapid recovery in total knee arthroplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Randomized controlled trial, Level I.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2367-5","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:09:51Z","timestamp":1357776591000},"page":"1638-1643","source":"Crossref","is-referenced-by-count":98,"title":["Effects of dexamethasone on local infiltration analgesia in total knee arthroplasty: a randomized controlled trial"],"prefix":"10.1002","volume":"22","author":[{"given":"Masahiko","family":"Ikeuchi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Kochi University 185\u20101 Oko\u2010cho, Nankoku 783\u20108505 Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kamimoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kochi University Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kochi University 185\u20101 Oko\u2010cho, Nankoku 783\u20108505 Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kochi University Kochi 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