{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:27:55Z","timestamp":1791559675702,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this systematic review is to analyse the current knowledge, incidence, relevance, and need for treatment of bone bruises associated with acute ankle ligament injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search was made of PubMed, OVID\/Medline, Cochrane databases using the keyword \u201cbone bruises\u201d in combination with \u201cankle\u201d, \u201csprain\u201d, \u201cmanagement\u201d, \u201csurgery\u201d, and \u201cconservative treatment\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No randomized controlled trials or prospective cohort studies were found. Only case series were retrieved. A critical appraisal for validity and usefulness of the studies revealed that the best level of evidence on this topic is represented by retrospective comparative studies. Nine studies evaluating the management of bone bruises associated with acute ankle ligament injuries were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical prognosis of bone bruises is generally good, with a normalization of MRI appearance usually within 6\u201312\u00a0months after trauma. Currently, there is no evidence that these lesions need specific treatment. Thus, the management of the concomitant ligament lesions is sufficient. Further research is necessary to successfully address the management of bone bruises, and more evidence is required to decide if these lesions need to be treated at all.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2383-5","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T06:06:51Z","timestamp":1358489211000},"page":"1261-1268","source":"Crossref","is-referenced-by-count":21,"title":["Bone bruises associated with acute ankle ligament injury: do they need treatment?"],"prefix":"10.1002","volume":"21","author":[{"given":"Umile Giuseppe","family":"Longo","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic and Trauma Surgery Campus Bio\u2010Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Loppini","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic and Trauma Surgery Campus Bio\u2010Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Romeo","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic and Trauma Surgery Campus Bio\u2010Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Niek","family":"van Dijk","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Orthopaedic Surgery, Academic Medical Center University of Amsterdam PO Box 22700 1100 DE Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry Mile End Hospital 275 Bancroft Road E1 4DG London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Denaro","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic and Trauma Surgery Campus Bio\u2010Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome 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