{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:32:43Z","timestamp":1784640763425,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this work is to investigate the feasibility of non\u2010autologous transplantation of human mesenchymal stem cells (hMSCs) with or without differentiation for the regeneration of osteochondral defects in rabbits using a biphasic composite construct composed of platelet\u2010rich fibrin glue (PR\u2010FG) and hydroxyapatite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After isolation and culture, hMSCs were seeded on biphasic composite constructs (hydroxyapatite + PR\u2010FG) and transplanted into osteochondral defects of adult New Zealand white rabbits. Treatment of individual defects was applied by random assignment to one of five groups: (1) control, defects untreated; (2) hydroxyapatite, defects filled with hydroxyapatite only; (3) hydroxyapatite + PR\u2010FG, defects filled with a composite of hydroxyapatite and PR\u2010FG; (4) hydroxyapatite + PR\u2010FG + undifferentiated hMSCs; and (5) hydroxyapatite + PR\u2010FG + differentiated hMSCs. Rabbits were killed at 4 or 8 weeks post\u2010surgery, at which time osteochondral repair was macroscopically and histologically evaluated and scored using the modified International Cartilage Repair Society scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The group in which defects were seeded with differentiated hMSCs (group 5) showed superior healing of osteochondral defects based on macroscopic and histological observations compared to other groups. Specifically, 8 weeks after implantation, defects were filled with more hyaline\u2010like cartilage and were better integrated with the surrounding native cartilage. The histological scores were significantly better than those of other groups (16.3 at 8 weeks, <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Xenogeneic transplantation of differentiated hMSCs using a biphasic composite construct effectively repaired osteochondral defect in a rabbit model. Differentiated hMSCs showed superior healing of chondral lesion to undifferentiated hMSCs.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2426-y","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T05:52:56Z","timestamp":1359525176000},"page":"1434-1444","source":"Crossref","is-referenced-by-count":40,"title":["Xenotransplantation of human mesenchymal stem cells for repair of osteochondral defects in rabbits using osteochondral biphasic composite constructs"],"prefix":"10.1002","volume":"22","author":[{"given":"Ki\u2010Mo","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Samsung Medical Center Sungkyunkwan University School of Medicine 50 Ilwon\u2010Dong 135\u2010710 Kangnam\u2010Gu, Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Ansan Hospital Korea University School of Medicine Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Guro Hospital Korea University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae\u2010Ryong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Guro Hospital Korea University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Ho","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Samsung Medical Center Sungkyunkwan University School of Medicine 50 Ilwon\u2010Dong 135\u2010710 Kangnam\u2010Gu, Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1198"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2002.tb03061.x"},{"key":"e_1_2_7_4_1","first-page":"287","article-title":"Graft\u2010versus\u2010host disease: emerging concepts in prevention and therapy","volume":"2","author":"Dean RM","year":"2003","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31156"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510366027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31818f8c20"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142\u20109612(02)00148\u20105"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20442"},{"key":"e_1_2_7_10_1","first-page":"27","article-title":"Species differences in the ability of isolated epiphyseal chondrocytes to hypertrophy after transplantation into the wall of the Syrian hamster cheek pouch","volume":"28","author":"Kaminski MJ","year":"1980","journal-title":"Folia Biol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600845070"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200801000-00002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301\u2010472X(03)00110\u20103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.3405"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199108000-00037"},{"key":"e_1_2_7_17_1","first-page":"66","article-title":"Growth factors and articular cartilage","volume":"27","author":"Mankin HJ","year":"1991","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.1.4.539"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511398646"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.03.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.09.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0229"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000267918.07906.08"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0114"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240802419302"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.11.017"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21096"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010200005000\u201000020"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067\u20101927.2004.012309.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0189"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2615"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.10.011"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142\u20109612(02)00223\u20105"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010011\u20102107\u20104"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1516"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.05.064"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.05.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510365296"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-013-2426-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00167-013-2426-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-013-2426-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:04:53Z","timestamp":1760868293000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-013-2426-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,31]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1007\/s00167-013-2426-y"],"URL":"https:\/\/doi.org\/10.1007\/s00167-013-2426-y","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,31]]}}}