{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:45:58Z","timestamp":1787319958693,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T00:00:00Z","timestamp":1362787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The objective of this study was to determine whether using mesenchymal stem cells (MSC) seeded in a collagen type I scaffold would be sufficient to regenerate the torn anterior cruciate ligament (ACL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Anterior cruciate ligament transection was performed on both knees in 10\u00a0New Zealand rabbits and then repaired with as follows: suture alone (suture\u2010treated group,\n                      <jats:italic>n<\/jats:italic>\n                      = 6), suture associated with collagen type I scaffold (collagen type I scaffold\u2010treated group,\n                      <jats:italic>n<\/jats:italic>\n                      = 8) or suture associated with autologous MSC seeded on collagen type I scaffold (MSC\/collagen type I scaffold\u2010treated group,\n                      <jats:italic>n<\/jats:italic>\n                      = 6). At 12\u2010week post\u2010intervention, the animals were killed and the ACLs were characterised macroscopically and histologically. Data of the 3\u00a0groups were against normal ACL (normal group,\n                      <jats:italic>n<\/jats:italic>\n                      = 10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Macroscopic observation found that in MSC\/collagen type I scaffold group, 33 % of specimens showed a complete ACL regeneration, with a tissue similar to the normal ACL. Regeneration was not observed in the group treated with suture alone or associated with collagen type I scaffold without cells. In the latter, only a reparative attempt at the ends was observed. Histological analysis of the regenerated ACL showed a tissue with organised collagen and peripheric vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results provide evidence that the use of MSC seeded in a collagen type I scaffold in the treatment of ACL injuries is associated with an enhancement of ligament regeneration. This MSC\u2010based technique is a potentially attractive tool for improving the treatment of ACL ruptures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-013-2471-6","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:57:28Z","timestamp":1362704248000},"page":"1196-1202","source":"Crossref","is-referenced-by-count":32,"title":["Anterior cruciate ligament regeneration using mesenchymal stem cells and collagen type I scaffold in a rabbit model"],"prefix":"10.1002","volume":"22","author":[{"given":"David","family":"Figueroa","sequence":"first","affiliation":[{"name":"Orthopedic Surgery Department Cl\u00ednica Alemana de Santiago Avda Vitacura 5951 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department Cl\u00ednica Alemana de Santiago Avda Vitacura 5951 Santiago Chile"},{"name":"Faculty of Medicine Cl\u00ednica Alemana\u2013Universidad del Desarrollo Las Condes 12438 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Calvo","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department Cl\u00ednica Alemana de Santiago Avda Vitacura 5951 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Scheu","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department Cl\u00ednica Alemana de Santiago Avda Vitacura 5951 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Vaisman","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department Cl\u00ednica Alemana de Santiago Avda Vitacura 5951 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Gallegos","sequence":"additional","affiliation":[{"name":"Pathology Department Cl\u00ednica Alemana de Santiago Vitacura 5951 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Conget","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Cl\u00ednica Alemana\u2013Universidad del Desarrollo Las Condes 12438 Santiago 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