{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:39:50Z","timestamp":1792651190016,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Our purpose was to evaluate the effectiveness of intra\u2010articular injections of hyaluronic acid (HA) into immobilized joints for reducing rigidity and formation of joint adhesions following surgery and prolonged joint immobilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four New Zealand white rabbits were randomly divided into experimental (<jats:italic>n<\/jats:italic> = 12) and control groups (<jats:italic>n<\/jats:italic> = 12). A model of knee injury was created in the right hind leg, and external plaster fixation was performed for 8 weeks. The experimental and control groups received weekly intra\u2010articular injections of 0.3\u00a0mL HA solution or normal saline, respectively, in the knee joint. The degree of adhesions, range of motion (ROM), and collagen content of the synovium of the knee joint were observed after 8 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of 8 weeks, the experimental compared with control group had significantly higher mean ROM (70.3\u00b0 \u00b1 11.1\u00b0 vs. 54.6\u00b0 \u00b1 11.2\u00b0, respectively; <jats:italic>P<\/jats:italic> = 0.002) and mean adhesion score. The experimental group compared with the control group had significantly lower mean adhesion score (2.2 \u00b1 0.9 vs. 3.1 \u00b1 0.7, respectively; <jats:italic>P<\/jats:italic> = 0.012) and collagen content (32.4 \u00b1 4.7 vs. 39.0 \u00b1 4.2 \u03bcg\/mg, <jats:italic>P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a rabbit model of knee injury, intra\u2010articular injection of HA decreased adhesion formation and collagen content and increased ROM after prolonged immobilization. These results indicate that HA may be clinically useful to prevent adhesions and improve joint mobility in patients who require joint immobilization for up to 8 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2547-3","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T08:31:37Z","timestamp":1370421097000},"page":"1536-1540","source":"Crossref","is-referenced-by-count":19,"title":["Intra\u2010articular injection of hyaluronic acid for the reduction in joint adhesion formation in a rabbit model of knee injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xinqiao Hospital Third Military Medical University No. 2 Xinqiao Street, Shapingba District 400037 Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xinqiao Hospital Third 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