{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:30:02Z","timestamp":1793313002025,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Autologous chondrocyte implantation (ACI) is an established procedure in the ankle providing satisfactory results. The development of a completely arthroscopic ACI procedure in the ankle joint made the technique easier and reduced the morbidity. The purpose of this investigation was to report the clinical results of a series of patients who underwent arthroscopic ACI of the talus at a mean of 7 \u00b1 1.2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six patients (mean age 31.4 \u00b1 7.6) affected by osteochondral lesions of the talar dome (OLT) received arthroscopic ACI between 2001 and 2006. Patients were clinically evaluated using AOFAS score pre\u2010operatively and at 12, 36\u00a0months and at final follow\u2010up of 87.2 \u00b1 14.5\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean pre\u2010operative AOFAS score was 57.2 \u00b1 14.3. At the 12\u2010month follow\u2010up, the mean AOFAS score was 86.8 \u00b1 13.4 (<jats:italic>p<\/jats:italic> = 0.0005); at 36\u00a0months after surgery, the mean score was 89.5 \u00b1 13.4 (<jats:italic>p<\/jats:italic> = 0.0005); whereas at final follow\u2010up of 87.2 \u00b1 14.5\u00a0months it was 92.0 \u00b1 11.2 (<jats:italic>p<\/jats:italic> = 0.0005). There were three failures. Histological and immunohistochemical evaluations of specimens harvested from failed implants generally showed several aspects of a fibro\u2010cartilaginous tissue associated with some aspects of cartilage tissue remodelling as indicated by the presence of type II collagen expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed the ability of arthroscopic ACI to repair osteochondral lesions in the ankle joint with satisfactory clinical results after mid\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV, retrospective case series.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2640-7","type":"journal-article","created":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T11:10:58Z","timestamp":1377947458000},"page":"1311-1319","source":"Crossref","is-referenced-by-count":80,"title":["Arthroscopic autologous chondrocyte implantation in the ankle 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