{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:34:43Z","timestamp":1784176483456,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to investigate the effect of a 6\u2010month period of intensive running followed by the participation at a marathon run on cartilage volume and thickness in knees of marathon beginners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten asymptomatic marathon beginners underwent a supervised 6\u2010month training program, which was finalized by the participation at a marathon run. Three\u2010dimensional quantitative magnetic resonance imaging was performed before the training program (baseline measurements) and 1\u00a0day after the marathon (follow\u2010up measurements). Cartilage volume and thickness of the medial and lateral femur, medial and lateral tibia, and patella were measured using semiautomated cartilage segmentation and three dimensional data postprocessing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences between baseline and follow\u2010up measurements were observed at the lateral femur, where cartilage volume and thickness decreased by a mean of 3.2 \u00b1 3.0 % (<jats:italic>p<\/jats:italic> = 0.012) and 1.7 \u00b1 1.6 % (<jats:italic>p<\/jats:italic> = 0.010), respectively. No significant changes in cartilage volume and thickness were observed at the medial and lateral tibia, the medial femur, and the patella.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant cartilage loss was observed at the lateral femur; however, the measured values are comparable to previously reported precision errors for quantitative cartilage measurement and thus most likely not of clinical relevance. High\u2010impact forces during long\u2010distance running are well tolerated even in marathon beginners and do not lead to clinical relevant cartilage loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2686-6","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T01:22:20Z","timestamp":1379380940000},"page":"1353-1359","source":"Crossref","is-referenced-by-count":13,"title":["The effect of a six\u2010month training program followed by a marathon run on knee joint cartilage volume and thickness in marathon beginners"],"prefix":"10.1002","volume":"22","author":[{"given":"Stefan","family":"Hinterwimmer","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Research Group for Kinematics and Biomechanics University of Frankfurt 60528 Frankfurt Germany"},{"name":"Sportsclinic Germany 81737 Munich 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