{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:49:29Z","timestamp":1789390169753,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Large osteochondral defects involve two different tissues characterized by different intrinsic healing capacity. Different techniques have been proposed to treat these lesions with results still under discussion. The aim of the study is to evaluate the clinical outcome of 19 patients treated with a type I collagen\u2013hydroxyapatite nanostructural biomimetic osteochondral scaffold at minimum follow\u2010up of 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty lesions, 19 patients were treated with this scaffold implantation. The lesions size went from 4 to 8\u00a0cm<jats:sup>2<\/jats:sup> (mean size 5.2 \u00b1 1.6\u00a0cm<jats:sup>2<\/jats:sup>). All patients were clinically evaluated using the International Repair Cartilage Society score, the Tegner Score and EQ\u2010VAS. MRI was performed at 12 and 24\u00a0months after surgery and then every 12\u00a0months and evaluated with magnetic resonance observation of cartilage repair tissue scoring scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IKDC subjective score improved from a mean score of 35.7 \u00b1 6.3 at the baseline evaluation to 67.7 \u00b1 13.4 at 12\u2010month follow\u2010up (<jats:italic>p<\/jats:italic> &lt; 0.0005). A further improvement was documented from 12 to 24\u00a0months (mean score of 72.9 \u00b1 12.4 at 24\u00a0months) (<jats:italic>p<\/jats:italic> &lt; 0.0005). The IKDC objective score confirmed the results. The Tegner activity score improvement was statistically significant (<jats:italic>p<\/jats:italic> &lt; 0.0005). The EQ\u2010VAS showed a significant improvement from 3.15 \u00b1 1.09 to 7.35 \u00b1 1.14 (<jats:italic>p<\/jats:italic> &lt; 0.0005) at 2\u2010year follow\u2010up. The lesion\u2019 site seems to influence the results showing a better outcome in the patients affected in the medial femoral condyle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of the MaioRegen scaffold is a good procedure for the treatment for large osteochondral defects where other classic techniques are difficult to apply. It is an open one\u2010step surgery with promising stable results at medium follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2717-3","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T08:37:14Z","timestamp":1382344634000},"page":"1260-1269","source":"Crossref","is-referenced-by-count":50,"title":["Use of innovative biomimetic scaffold in the treatment for large osteochondral lesions of the knee"],"prefix":"10.1002","volume":"22","author":[{"given":"Marco","family":"Delcogliano","sequence":"first","affiliation":[{"name":"University Hospital of Parma Via Gramsci 14 43126 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"de Caro","sequence":"additional","affiliation":[{"name":"University Hospital of Parma Via Gramsci 14 43126 Parma 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