{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:09:29Z","timestamp":1762898969125,"version":"build-2065373602"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether the static knee alignment affects articular cartilage ultrastructures when measured using T2 relaxation among asymptomatic subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both knee joints (<jats:italic>n<\/jats:italic> = 96) of 48 asymptomatic volunteers (26 females, 22\u00a0males; 25.4 \u00b1 1.7 years; no history of major knee trauma or surgery) were evaluated clinically (Lysholm, Tegner) and by MRI (hip\u2013knee\u2013ankle angle, standard knee protocol, T2\u00a0mapping). Group (<jats:italic>n<\/jats:italic> = 4) division was as follows: neutral (&lt;1\u00b0 varus\/valgus), mild varus (2\u00b0\u20134\u00b0 varus), severe varus (&gt;4\u00b0 varus) and valgus (2\u00b0\u20134\u00b0 valgus) deformity with <jats:italic>n<\/jats:italic> = 12 subjects\/group; <jats:italic>n<\/jats:italic> = 24\u00a0knees\/group. Regions of interest (ROI) for T2 assessment were placed within full\u2010thickness cartilage across the whole joint surface and were divided respecting compartmental as well as functional joint anatomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leg alignment was 0.7\u00b0 \u00b1 0.5\u00b0 varus among neutral, 3.0\u00b0 \u00b1 0.6\u00b0 varus among mild varus, 5.0\u00b0 \u00b1 1.1\u00b0 varus among severe varus and 2.5\u00b0 \u00b1 0.7\u00b0 valgus among valgus group subjects and thus significantly different. No differences between the groups emerged from clinical measures. No morphological pathology was detected in any knee joint. Global T2 values (42.3 \u00b1 2.3; 37.7\u201347.9\u00a0ms) of ROIs placed within every knee joint per subject were not different between alignment groups or between genders, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Static frontal plane leg malalignment does not affect cartilage ultrastructure among young, asymptomatic individuals as measured by T2 quantitative imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Cross\u2010sectional study, Level II\u2010III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2756-9","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T09:40:35Z","timestamp":1385631635000},"page":"1396-1403","source":"Crossref","is-referenced-by-count":5,"title":["Alignment does not influence cartilage T2\u00a0in asymptomatic knee joints"],"prefix":"10.1002","volume":"22","author":[{"given":"M.","family":"Sauerschnig","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Sports Medicine Klinikum Rechts der Isar Technische Universitaet Muenchen Ismaninger Str. 69 81675 Munich Germany"},{"name":"Department of Traumatology Klinikum Rechts der Isar Technische Universitaet Muenchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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