{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:05:24Z","timestamp":1781478324896,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This prospective study assessed the 10\u2010year clinical outcomes of periosteum autologous chondrocyte implantation (ACI) due to cartilage lesions of the femoral condyles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three of 45 patients (3 failures, 7\u00a0non\u2010responders, 2 others) were available for clinical and radiographic evaluation at 2, 5, and 10 years. Patients were categorized into groups with focal cartilage lesions, osteochondritis dissecans (OCD), and cartilage lesions with simultaneous ACL reconstruction (ACL). Seven patients in the overall series required an arthroscopic re\u2010intervention (3 ACI related, 4 ACI unrelated).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjective knee scores and activity scores were significantly improved at 2 years toward their pre\u2010operative levels and then remained stable up to 10 years; however, patients did not reach their pre\u2010injury activity levels. Upon 10\u2010year examination, using the IKDC knee examination form, there were 15\u00a0normal, 11\u00a0nearly normal, 5 abnormal, and 2 severely abnormal knees. Radiographic evidence of osteoarthritis was found in 45 % of patients (5 focal lesions, 2 OCD, and 8 ACL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACI provided safe and stable performance of operated knees over 10 years with a significant improvement toward pre\u2010operative levels. Patients restrained from high\u2010impact knee joint activities, post\u2010surgery, and their knee radiographs demonstrated a high incidence of knee OA in trauma\u2010related lesions. Optimal long\u2010term performance is expected in localized, low\u2010impact cartilage lesions of young patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Case series, Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2778-3","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T05:37:36Z","timestamp":1384925856000},"page":"1277-1283","source":"Crossref","is-referenced-by-count":41,"title":["Ten\u2010year clinical and radiographic outcomes after autologous chondrocyte implantation of femoral condyles"],"prefix":"10.1002","volume":"22","author":[{"given":"David","family":"Martin\u010di\u010d","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University Medical Centre Ljubljana Zalo\u0161ka ulica 9 1000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damjan","family":"Radosavljevi\u010d","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Medical Centre Ljubljana Zalo\u0161ka ulica 9 1000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Drobni\u010d","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Medical Centre Ljubljana Zalo\u0161ka ulica 9 1000 Ljubljana 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