{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:12:40Z","timestamp":1773515560235,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study is to conduct a meta\u2010analysis of randomized, controlled trials evaluating the efficacy and safety of intra\u2010articular injection of tranexamic acid (TXA) for reducing blood loss and transfusion in patients undergoing total knee arthroplasty (TKA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A meta\u2010analysis was conducted of RCTs published before March 2013, identified from the PubMed, EMBase, Cochrane library, ScienceDirect, and other databases. Two independent reviewers assessed the methodological quality of the studies and performed data extraction. Mean difference in blood loss and blood transfusions, risk ratios of transfusion rates, and deep vein thrombosis (DVT) incidence in the TXA\u2010treated group versus placebo group were pooled from the included studies. Data were analysed using Stata 11.0 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies were included, with a total sample size of 647 patients. The use of TXA significantly reduced total blood loss (mean difference: \u2212344.96; 95 % confidence interval (CI) \u2212401.20 to \u2212239.68; <jats:italic>P<\/jats:italic> &lt; 0.01) and the proportion of patients requiring blood transfusions (risk ratios, 0.28; 95 % CI: 0.19\u20130.42; <jats:italic>P<\/jats:italic> &lt; 0.01). There were no significant differences in the incidence of DVT, pulmonary embolism, or other complications between the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present meta\u2010analysis indicated that intra\u2010articular injection of TXA in patients undergoing TKA may reduce total blood loss and the need for blood transfusions, particularly when a high dosage of TXA is used (\u226530\u00a0mg\/ml), without any increase in the risk of post\u2010operative DVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>II.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2814-3","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T09:49:16Z","timestamp":1387360156000},"page":"3181-3190","source":"Crossref","is-referenced-by-count":54,"title":["Reduced blood loss after intra\u2010articular tranexamic acid injection during total knee arthroplasty: a meta\u2010analysis of the literature"],"prefix":"10.1002","volume":"22","author":[{"given":"Chen","family":"Zhao\u2010yu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Third Hospital of Hebei Medical University 050051 Shijiazhuang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Third Hospital of Hebei Medical University 050051 Shijiazhuang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Third Hospital of Hebei Medical University 050051 Shijiazhuang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yuejv","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Third Hospital of Hebei Medical University 050051 Shijiazhuang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Ying\u2010ze","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Third Hospital of Hebei Medical University 050051 Shijiazhuang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.12.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199901000-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2003.10.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32832c5280"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2005.00204.x"},{"key":"e_1_2_6_7_1","first-page":"271","article-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991\u201094","volume":"33","author":"Dillon CF","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539\u2010200011000\u201000014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102482\u201011\u201029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20108090\u20104\u201025"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.07.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002640100227"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010012\u20102488\u2010z"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg111"},{"key":"e_1_2_6_15_1","first-page":"83","article-title":"The relationship between hematocrit, blood lost, and blood transfused in total knee replacement. 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