{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:41:07Z","timestamp":1773675667509,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR055563\/AR\/NIAMS"],"award-info":[{"award-number":["R01\u2010AR055563\/AR\/NIAMS"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In an effort to identify risk factors for anterior cruciate ligament (ACL) injury, many potential risk factors have been proposed, including familial predisposition. However, no study has evaluated familial predisposition in male or females separately. The purpose of this study was to determine whether a familial predisposition to ACL injury exists in both males and females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty (78\u00a0males and 42 females) patients who had undergone surgical ACL reconstruction were recruited as the ACL group, and 107 patients (67\u00a0males and 40 females) that had undergone arthroscopic partial menisectomy, with no previous history of ACL injury, were recruited as the referent control group. A familial ACL injury and subject particulars questionnaire was completed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When all subjects were combined, the ACL group (20.0 %, 24 of 120) did not demonstrate a higher familial (first\u2010degree relative) prevalence (n.s.) of ACL injury compared to the referent control group (15.0 %; 16 of 107 patients). When the data were stratified by sex, the male ACL group (19.2 %, 15 of 78) demonstrated a significantly higher familial (first\u2010degree relative) prevalence (<jats:italic>P<\/jats:italic> = 0.02) of ACL injury compared to the male referent control group (7.5 %; 5 of 67 patients). There were no differences among the females (n.s.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results of this study show that male patients with ACL tears are more likely to have a first\u2010degree relative with an ACL tear compared to male referent control subjects. Future research is warranted to better delineate sex\u2010specific risk factors for ACL injuries could help guide intervention programs aimed at preventative treatment strategies, especially in high\u2010risk families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-013-2822-3","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T22:55:33Z","timestamp":1389135333000},"page":"387-391","source":"Crossref","is-referenced-by-count":18,"title":["Sex comparison of familial predisposition to anterior cruciate ligament injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Gregory D.","family":"Myer","sequence":"first","affiliation":[{"name":"Division of Sports Medicine Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue, MLC 10001 45229 Cincinnati OH USA"},{"name":"Departments of Pediatrics and Orthopaedic Surgery University of Cincinnati Cincinnati OH USA"},{"name":"The Micheli Center for Sports Injury Prevention Waltham MA USA"},{"name":"The Sports Health and Performance Institute OSU Sports Medicine Ohio State University Medical Center Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Heidt","sequence":"additional","affiliation":[{"name":"Wellington Orthopaedic and Sports Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Waits","sequence":"additional","affiliation":[{"name":"Wellington Orthopaedic and Sports Medicine Cincinnati OH USA"},{"name":"Hendricks Orthopedics and Sports Medicine Danville IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Finck","sequence":"additional","affiliation":[{"name":"Wellington Orthopaedic and Sports Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denver","family":"Stanfield","sequence":"additional","affiliation":[{"name":"Wellington Orthopaedic and Sports Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Posthumus","sequence":"additional","affiliation":[{"name":"UCT\/MRC Research Unit for Exercise Science and Sports Medicine The University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Hewett","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Family Medicine The Ohio State University Columbus OH USA"},{"name":"Division of Sports Medicine Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue, MLC 10001 45229 Cincinnati OH USA"},{"name":"Departments of Pediatrics and Orthopaedic Surgery University of Cincinnati Cincinnati OH USA"},{"name":"The Sports Health and Performance Institute OSU Sports Medicine Ohio State University Medical Center Columbus OH USA"},{"name":"Department of Physiology and Cell Biology The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504269937"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"Alentorn\u2010GeliE MendiguchiaJ SamuelssonK MusahlV KarlssonJ CugatR MyerGDPrevention of non\u2010contact anterior cruciate ligament injuries in sports. 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