{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:23:52Z","timestamp":1793283832969,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:00:00Z","timestamp":1426291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:00:00Z","timestamp":1426291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the pre\u2010soaking of hamstring grafts in topical vancomycin, in addition to IV prophylaxis, during anterior cruciate ligament (ACL) reconstruction to reduce the incidence of post\u2010operative infection, and to describe an evidence\u2010based diagnostic and treatment algorithm to facilitate early diagnosis and appropriate management of possible knee sepsis post\u2010operatively after ACL reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a controlled observational series comprising of 1585\u00a0individuals who underwent ACL reconstruction over a 13\u2010year period. All surgeries were performed by a single surgeon at the same hospital. Group 1 consisted of 285 patients who received pre\u2010operative IV antibiotics without topical graft pre\u2010soaking. Group 2 consisted of 1300\u00a0individuals who received IV antibiotics and graft pre\u2010soaking in a vancomycin solution of 5\u00a0mg\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In group 1, a total of four patients suffered a post\u2010operative joint infection (1.4 %). Three out of the four were culture positive for Staphylococcus species. The fourth was culture negative but was managed as an acute infection. Group 2 suffered no post\u2010operative infections (0 %). Statistical analysis of the vancomycin pre\u2010soak with IV antibiotics group, compared with IV antibiotics\u2010alone group, revealed a significantly reduced post\u2010operative infection rate using a Fisher's exact test (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0011) and Chi\u2010square test with Yates\u2019 correction (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre\u2010soaking of hamstrings grafts with topical vancomycin reduced the rate of post\u2010operative infection when compared to IV antibiotics alone. This technique should be utilised by surgeons to reduce the overall incidence of knee sepsis post\u2010ACL reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-015-3558-z","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T11:21:54Z","timestamp":1426245714000},"page":"2729-2735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["No infections in 1300 anterior cruciate ligament reconstructions with vancomycin pre\u2010soaking of hamstring grafts"],"prefix":"10.1002","volume":"24","author":[{"given":"Michael","family":"Phegan","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Gold Coast University Hospital 1 Hospital Boulevard 4215 Southport, Gold Coast QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Grayson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Sciences Stephen F. Austin State University Nacogdoches TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Vertullo","sequence":"additional","affiliation":[{"name":"Knee Research Australia Centre for Musculoskeletal Research Griffith University Gold Coast QLD 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