{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:12:04Z","timestamp":1785240724976,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de la Hanche et du Genou"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Revision of infected total knee replacements (TKR) is usually delayed for a period in which the joint space is filled with an antibiotic\u2010loaded acrylic spacer. In contrast, one\u2010stage re\u2010implantation supposes immediate re\u2010implantation. Formal comparisons between the two methods are scarce. A retrospective multi\u2010centre study was conducted to investigate the effects of surgery type (one\u2010stage vs. two\u2010stage) on cure rates. It was hypothesised that this parameter would not influence the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All infected TKR, treated consecutively between 2005 and 2010 by senior surgeons working in six referral hospitals, were included retrospectively. Two hundred and eighty\u2010five patients, undergoing one\u2010stage or two\u2010stage TKR, with more than 2\u2010year follow\u2010up (clinical and radiological) were eligible for data collection and analysis. Of them, 108 underwent one\u2010stage and 177 received two\u2010stage TKR. Failure was defined as infection recurrence or persistence of the same or unknown pathogens. Factors linked with infection recurrence were analysed by uni\u2010 and multi\u2010variate logistic regression with random intercept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factors associated with infection recurrence were fistulae (odds ratio (OR) 3.4 [1.2\u201310.2], <jats:italic>p<\/jats:italic> = 0.03), infection by gram\u2010negative bacteria (OR 3.3 [1.0\u201310.6], <jats:italic>p<\/jats:italic> = 0.05), and two\u2010stage surgery with static spacers (OR 4.4 [1.1\u201317.9], <jats:italic>p<\/jats:italic> = 0.04). Gender and type of surgery interacted (<jats:italic>p<\/jats:italic> = 0.05). In men (133 patients), type of surgery showed no significant linkage with infection recurrence. In women (152 patients), two\u2010stage surgery with static spacers was associated independently with infection recurrence (OR 5.9 [1.5\u201323.6], <jats:italic>p<\/jats:italic> = 0.01). Among patients without infection recurrence, International Knee Society scores were similar between those undergoing one\u2010stage or two\u2010stage exchanges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two\u2010stage procedures offered less benefit to female patients. It suggests that one\u2010stage procedures are preferable, because they offer greater comfort without increasing the risk of recurrence. Routine one\u2010stage procedures may be a reasonable option in the treatment of infected TKR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-015-3884-1","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T09:38:33Z","timestamp":1448530713000},"page":"3131-3139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Infection recurrence factors in one\u2010 and two\u2010stage total knee prosthesis exchanges"],"prefix":"10.1002","volume":"24","author":[{"given":"P.","family":"Massin","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery H\u00f4pital Bichat Claude Bernard Universit\u00e9 Paris\u2010Diderot 46 rue Henri Huchard 75877 Paris Cedex 18 France"},{"name":"EA 7334 Recherche Clinique Coordonn\u00e9e Ville\u2010H\u00f4pital M\u00e9thodologies et Soci\u00e9t\u00e9 Universit\u00e9 Paris\u2010Diderot Sorbonne Paris Cit\u00e9 75010 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Delory","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Clinical Research H\u00f4pitaux Universitaires Paris Nord Val de Seine Site Bichat, 46, rue Henri\u2010Huchard 75877 Paris Cedex 18 France"},{"name":"INSERM CIC\u2010EC 1425 75018 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lhotellier","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Diaconesse Croix Saint Simon 125 rue d'Avron 75020 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pasquier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Roger Salengro 59037 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Roche","sequence":"additional","affiliation":[{"name":"Centre Chirurgical Emile Gall\u00e9 49 rue Hermite 54000 Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cazenave","sequence":"additional","affiliation":[{"name":"Institut Calot rue du Docteur Calot 62600 Berck Sur Mer France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Estellat","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Clinical Research H\u00f4pitaux Universitaires Paris Nord Val de Seine Site Bichat, 46, rue Henri\u2010Huchard 75877 Paris Cedex 18 France"},{"name":"INSERM CIC\u2010EC 1425 75018 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Jenny","sequence":"additional","affiliation":[{"name":"Centre de Chirurgie Orthop\u00e9dique et de la Main H\u00f4pitaux Universitaires de Strasbourg 10 Avenue Baumann 67400 Illkirch\u2010Graffenstaden France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010012\u20102090\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035\u20101040(06)75930\u2010X"},{"key":"e_1_2_9_4_1","first-page":"190","article-title":"Primary exchange revision arthroplasty for infected total knee replacement: a long\u2010term study","volume":"33","author":"Buechel FF","year":"2004","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.09.033"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01070"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2004.02.036"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.74B1.1732271"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010199610000\u201000016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010014\u20103721\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000147713.64235.73"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0883\u20105403(98)90071\u20107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198911000-00004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365080-00008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670902805064"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010012\u20102480\u20107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2011.05.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001105010086"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20100691.2006.01378.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010008\u20100230\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2012.05.019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010200210000\u201000003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010012\u20101885\u2010x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir402"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818067.ch9"},{"key":"e_1_2_9_26_1","first-page":"244","article-title":"Mid\u2010 to long\u2010term results after treatment of 118 cases of periprosthetic infections after knee joint replacement using one\u2010stage exchange surgery","volume":"20","author":"Foerster G","year":"1991","journal-title":"Orthopade"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072020-00017"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-015-3884-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00167-015-3884-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-015-3884-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-015-3884-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:29:07Z","timestamp":1760869747000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-015-3884-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1007\/s00167-015-3884-1"],"URL":"https:\/\/doi.org\/10.1007\/s00167-015-3884-1","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}