{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:51:22Z","timestamp":1793724682197,"version":"4.6.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to assess whether the neutrophil\u2010to\u2010lymphocyte ratio (NLR) distribution could have a better kinetic pattern than C\u2010reactive protein (CRP) distribution to evaluate early post\u2010operative inflammation after total knee arthroplasty (TKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study was performed on 587 patients. CRP and NLR were collected pre\u2010operatively and at post\u2010operative days 2, 4, 21 and 42. Mean peak values and distribution were compared between CRP and NLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean CRP levels were 163, 161, 9 and 7\u00a0mg\/L, respectively, at days 2, 4, 21 and 42. Mean NLR levels were 5, 3.5, 2.6 and 2.5, respectively, at days 2, 4, 21 and 42. At days 21 and 42, 20 % (102\/503) and 21 % (93\/433) of patients had not reached normal CRP levels. At day 21, there were 4.5 % (23\/503) of patients with a NLR &gt; 5 and 1 % (5\/503) with an NLR &gt; 10. At day 42, there were 5.5 % (24\/433) of patients with an NLR &gt; 5 and 0.7 % (3\/433) with an NLR &gt; 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR has a faster normalization than CRP. It is potentially a better biomarker to follow post\u2010operative inflammation or early infection after TKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>II<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-015-3921-0","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T01:21:12Z","timestamp":1450920072000},"page":"3287-3292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Neutrophil\u2010to\u2010lymphocyte ratio (NLR) distribution shows a better kinetic pattern than C\u2010reactive protein distribution for the follow\u2010up of early inflammation after total knee arthroplasty"],"prefix":"10.1002","volume":"24","author":[{"given":"J. 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