{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:42:15Z","timestamp":1770061335394,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2010-2312173"],"award-info":[{"award-number":["RF-2010-2312173"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Benefits of an early reconstruction and the optimal time lapse between injury and surgery to reduce the effects of altered kinematics in ACL\u2010deficient knees are still controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to clarify, through a quantitative in vivo evaluation, the effects of the time lapse between ACL injury and surgery in terms of changes in the pre\u2010operative knee laxity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An in vivo study was performed on 99 patients who underwent ACL surgery. Just before the graft fixation, six laxity tests were performed for all the subjects at manual\u2010maximum load: anterior\u2013posterior displacement and internal\u2013external rotation at 30\u00b0 and 90\u00b0 of knee flexion (AP30, AP90, IE30, IE90) as well as varus\u2013valgus rotation (VV0, VV30) at 0\u00b0 and 30\u00b0 of flexion. Kinematics data were acquired by a navigation system. The Spearman rank correlation was used to assess correlation between rank and continuous data. Significance was set at <jats:italic>P<\/jats:italic> = 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis highlighted a significant influence of the injury\u2010to\u2010surgery time lapse on VV0 and AP90 compared with pre\u2010operative laxity levels. Meniscus status also significantly affected the pre\u2010operative laxity in the VV0 (Spearman's<jats:italic>\u03c1<\/jats:italic> = 0.203, <jats:italic>P<\/jats:italic> = 0.038; GLM with meniscal correction partial <jats:italic>\u03b7<\/jats:italic> = 0.27, <jats:italic>P<\/jats:italic> = 0.007) and AP90 (Spearman's <jats:italic>\u03c1<\/jats:italic> = 0.329, <jats:italic>P<\/jats:italic> = 0.001; GLM with meniscal correction partial <jats:italic>\u03b7<\/jats:italic> = 0.318, <jats:italic>P<\/jats:italic> = 0.017) tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The main finding of this study is that patients with ACL rupture and a higher injury\u2010to\u2010surgery time present higher values of knee laxity involving AP90 displacement and VV30 rotation. Clinical relevance of the study is that ACL\u2010deficient joint laxity, involving anterior\u2013posterior displacement at 90\u00b0 of knee flexion and varus\u2013valgus rotation at 0\u00b0 of flexion, is significantly affected by the lapse of injury\u2010to\u2010surgery time. This highlights the importance of considering the effects of delaying surgery when managing patients with such deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-016-4158-2","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T02:27:59Z","timestamp":1465266479000},"page":"3605-3611","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["ACL rupture and joint laxity progression: a quantitative in vivo analysis"],"prefix":"10.1002","volume":"24","author":[{"given":"C.","family":"Signorelli","sequence":"first","affiliation":[{"name":"Laboratorio di Biomeccanica e Innovazione Tecnologica Istituto Ortopedico Rizzoli Via Di Barbiano 1\/10 40136 Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Filardo","sequence":"additional","affiliation":[{"name":"Laboratorio Nano\u2010Biotechnology NaBi Istituto Ortopedico Rizzoli Bologna BO Italy"},{"name":"Clinica Ortopedica e Traumatologica I Istituto Ortopedico Rizzoli Via Pupilli 1 40136 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bonanzinga","sequence":"additional","affiliation":[{"name":"Laboratorio di Biomeccanica e Innovazione Tecnologica Istituto Ortopedico Rizzoli Via Di Barbiano 1\/10 40136 Bologna BO Italy"},{"name":"Clinica Ortopedica e Traumatologica I Istituto Ortopedico Rizzoli Via Pupilli 1 40136 Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Grassi","sequence":"additional","affiliation":[{"name":"Laboratorio di Biomeccanica e Innovazione Tecnologica Istituto Ortopedico Rizzoli Via Di Barbiano 1\/10 40136 Bologna BO Italy"},{"name":"Clinica Ortopedica e Traumatologica I Istituto Ortopedico Rizzoli Via Pupilli 1 40136 Bologna 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