{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:11:05Z","timestamp":1791317465496,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Laboratory diagnostics are part of the routine before and after operations. In all specialist surgical disciplines, including orthopaedic surgery, the acute\u2010phase protein CRP is used to detect inflammatory processes, especially infections. The potential influence of patient gender on the postoperative course of CRP after TKA implantation is still unclear. In order to achieve a more precise evaluation of the complication\u2010free general CRP course after TKA, the objective of the present study is to test the hypothesis that the p.o. course and level of CRP is gender specific in the first 10\u00a0days after TKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1068 consecutive patients who had been treated with a unilateral primary cemented total knee replacement due to primary osteoarthritis of the knee over a 36\u2010month period were retrospectively included in the study. For all patients, the preoperative CRP value and the postoperative course of CRP from postoperative days 1\u201310 were recorded and tested for gender specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On days 2\u20135 and 7\u20138 after surgery, men had significantly higher CRP values than women. The maximum difference was 45\u00a0mg\/L on the fourth p.o. day (men 170\u00a0mg\/L, women 125\u00a0mg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study was able to show, for the first time, that the complication\u2010free course of CRP in the first 10\u00a0days after TKA implantation is gender specific. The impact of the finding on diagnostic is that the gender\u2010specific CRP course provides a more precise evaluation of the complication\u2010free course of CRP after TKA. These results have clinical relevance to the interpretation of postoperative CRP values in order to avoid unnecessary investigations such as puncture or surgical care in female and male patients with uncomplicated TKA.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Level of evidence<\/jats:italic>\n                      Diagnostic study, III.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-016-4289-5","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T06:25:38Z","timestamp":1471415138000},"page":"3163-3167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The C\u2010reactive protein level after total knee arthroplasty is gender specific"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-020X","authenticated-orcid":false,"given":"Christoph","family":"Windisch","sequence":"first","affiliation":[{"name":"Orthopaedic Department Friedrich\u2010Schiller University Jena Campus Eisenberg, Klosterlausnitzer Stra\u00dfe 81 07607 Eisenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Brodt","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Friedrich\u2010Schiller University Jena Campus Eisenberg, Klosterlausnitzer Stra\u00dfe 81 07607 Eisenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Roehner","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Friedrich\u2010Schiller University Jena Campus Eisenberg, Klosterlausnitzer Stra\u00dfe 81 07607 Eisenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Matziolis","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Friedrich\u2010Schiller University Jena Campus Eisenberg, Klosterlausnitzer Stra\u00dfe 81 07607 Eisenberg 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