{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:14:41Z","timestamp":1773774881801,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Previous research has provided evidence of a hereditary predisposition for anterior cruciate ligament (ACL) injury. The purpose of this study was to evaluate the association between ancestral population genetics and risk of non\u2010contact ACL injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were collected from 177\u00a0individuals with a history of non\u2010contact ACL injury and 556\u00a0non\u2010injured control individuals for analysis of the genetic material through the use of a panel of 48 INDELs ancestry genetic markers from three ancestral origins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among patients with non\u2010contact ACL injury, 82% were male and 18% were female. In the control group, 78% were male, and 22% were female. The mean age of the non\u2010contact ACL injury group was 31.7 years (\u00b1\u200910.2), and the control group was 33.8 years (\u00b1\u200913.2). The individual genetic contribution from INDELs of each ancestral origin varied considerably: ranging between 1.5\u201394.8% contribution for INDELs of African origin (mean of 21.4% of INDELs); between 2 and 96.1% contribution for INDELs of European origin (mean of 66.7% of INDELs); and between 1.3\u201396.4% contribution for INDELs of Amerindian origin (mean of 11.7% of INDELs). When comparing paired subjects from the non\u2010contact ACL and control groups, the genetic analysis showed that the European ancestry score was higher in the non\u2010contact ACL group than control group (0.70\u2009\u00b1\u20090.21 vs 0.63\u2009\u00b1\u20090.22 respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas African ancestry scores (ACL group 0.18\u2009\u00b1\u20090.18 vs control group 0.24\u2009\u00b1\u20090.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and Amerindian ancestry scores (ACL group 0.11\u2009\u00b1\u20090.09 vs control group 0.12\u2009\u00b1\u20090.10, n.s.) were lower among the non\u2010contact ACL group than in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>European INDELs markers were found to represent a potential genetic predisposition for non\u2010contact ACL injuries when compared to African and Amerindian INDELs. This study has the potential to correlate a measurable and distinct genetic marker with risk of a non\u2010contact ACL injury. Thus, it increases knowledge base and volume of molecular and genetical factors associated with this pathology. Furthermore, this study provides guidance and evidence for the development of genetic risk\u2010screening panels for non\u2010contact ACL injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level III Diagnostic Study.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-018-4974-7","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T12:30:30Z","timestamp":1525437030000},"page":"3532-3536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The potential European genetic predisposition for non\u2010contact anterior cruciate ligament injury"],"prefix":"10.1002","volume":"26","author":[{"given":"Diego Costa","family":"Astur","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Centro de Traumatologia do Esporte Orthopaedic Surgeon from Universidade Federal de S\u00e3o Paulo Av Pacaembu 1024 01234\u2010000 S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilson","family":"Andrade","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Centro de Traumatologia do Esporte Orthopaedic Surgeon from Universidade Federal de S\u00e3o Paulo Av Pacaembu 1024 01234\u2010000 S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Gon\u00e7alves","family":"Arliani","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Centro de Traumatologia do Esporte Orthopaedic Surgeon from Universidade Federal de S\u00e3o Paulo Av Pacaembu 1024 01234\u2010000 S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Debieux","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Centro de Traumatologia do Esporte Orthopaedic Surgeon from Universidade Federal de S\u00e3o Paulo Av Pacaembu 1024 01234\u2010000 S\u00e3o Paulo SP 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Ferreira","family":"Leal","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Genetics and Othopaedics and Traumatology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Cohen","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Centro de Traumatologia do Esporte Orthopaedic Surgeon from Universidade Federal de S\u00e3o Paulo Av Pacaembu 1024 01234\u2010000 S\u00e3o Paulo SP 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December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental study was approved by the institutional research ethics committee, protocol 51436.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}