{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:53:02Z","timestamp":1783720382461,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee Surg Sports Traumatol Arthrosc"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00167-018-5079-z","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T04:52:55Z","timestamp":1533099175000},"page":"773-781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical and radiographic outcomes of chitosan-glycerol phosphate\/blood implant are similar with hyaluronic acid-based cell-free scaffold in the treatment of focal osteochondral lesions of the knee joint"],"prefix":"10.1002","volume":"27","author":[{"given":"Hakan","family":"Sofu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalkin","family":"Camurcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanifi","family":"Ucpunar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seckin","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Yurten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"issue":"Suppl 4","key":"5079_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0020-1383(15)30012-7","volume":"46","author":"P Angele","year":"2015","unstructured":"Angele P, Fritz J, Albrecht D, Koh J, Zellner J (2015) Defect type, localization and marker gene expression determines early adverse events of matrix-associated autologous chondrocyte implantation. Injury 46(Suppl 4):2\u20139","journal-title":"Injury"},{"issue":"4","key":"5079_CR2","doi-asserted-by":"publisher","first-page":"444","DOI":"10.5312\/wjo.v5.i4.444","volume":"5","author":"S Bark","year":"2014","unstructured":"Bark S, Piontek T, Behrens P, Mkalaluh S, Varoga D, Gille J (2014) Enhanced microfracture techniques in cartilage knee surgery: fact or fiction? World J Orthop 5(4):444\u2013449","journal-title":"World J Orthop"},{"issue":"7","key":"5079_CR3","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s00402-015-2235-5","volume":"135","author":"C Becher","year":"2015","unstructured":"Becher C, Ettinger M, Ezechieli M, Kaps C, Ewig M, Smith T (2015) Repair of retropatellar cartilage defects in the knee with microfracture and a cell-free polymer-based implant. Arch Orthop Trauma Surg 135(7):1003\u20131010","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"5079_CR4","first-page":"260","volume":"76","author":"JP Benthien","year":"2010","unstructured":"Benthien JP, Behrens P (2010) Autologous matrix-induced chondrogenesis (AMIC). A one-step procedure for retropatellar articular resurfacing. Acta Orthop Belg 76(2):260\u2013263","journal-title":"Acta Orthop Belg"},{"issue":"2","key":"5079_CR5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5606\/ehc.2015.19","volume":"26","author":"A Berta","year":"2015","unstructured":"Berta A, Duska Z, Toth F, Hangody L (2015) Clinical experiences with cartilage repair techniques: outcomes, indications, contraindications and rehabilitation. Eklem Hastalik Cerrahisi 26(2):84\u201396","journal-title":"Eklem Hastalik Cerrahisi"},{"issue":"10","key":"5079_CR6","first-page":"p32","volume":"33","author":"BR Blisard","year":"2013","unstructured":"Blisard BR (2013) Lesion size should not be a limitation for microfracture surgery. Orthopedics Today 33(10):p32","journal-title":"Orthopedics Today"},{"issue":"6","key":"5079_CR7","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s00167-013-2717-3","volume":"22","author":"M Delcogliano","year":"2014","unstructured":"Delcogliano M, de Caro F, Scaravella E, Ziveri G, De Biase CF (2014) Use of innovative biomimetic scaffold in the treatment for large osteochondral lesions of the knee. Knee Surg Sports Traumatol Arthrosc 22(6):1260\u20131269","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"5079_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.arthro.2012.05.891","volume":"29","author":"G Filardo","year":"2013","unstructured":"Filardo G, Kon E, Roffi A, Di Martino A, Marcacci M (2013) Scaffold-based repair for cartilage healing: a systematic review and technical note. Arthroscopy 29(1):174\u2013186","journal-title":"Arthroscopy"},{"issue":"9","key":"5079_CR9","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1007\/s00167-013-2676-8","volume":"22","author":"A Gobbi","year":"2014","unstructured":"Gobbi A, Karnatzikos G, Kumar A (2014) Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes. Knee Surg Sports Traumatol Arthrosc 22(9):1986\u20131996","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"10","key":"5079_CR10","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1007\/s00167-011-1840-2","volume":"20","author":"T Kusano","year":"2012","unstructured":"Kusano T, Jakob RP, Gautier E, Magnussen RA, Hoogewoud H, Jacobi M (2012) Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC). Knee Surg Sports Traumatol Arthrosc 20(10):2109\u20132115","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"5079_CR11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.arthro.2014.11.017","volume":"31","author":"E Kon","year":"2015","unstructured":"Kon E, Roffi A, Filardo G, Tesei G, Marcacci M (2015) Scaffold-based cartilage treatments: with or without cells? A systematic review of preclinical and clinical evidence. Arthroscopy 31(4):767\u2013775","journal-title":"Arthroscopy"},{"key":"5079_CR12","doi-asserted-by":"publisher","first-page":"204173141455270","DOI":"10.1177\/2041731414552701","volume":"5","author":"M Lach","year":"2014","unstructured":"Lach M, Trzeciak T, Richter M, Pawlicz J, Suchorska WM (2014) Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment. J Tissue Eng 5:2041731414552701","journal-title":"J Tissue Eng"},{"issue":"3","key":"5079_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/1947603514529445","volume":"5","author":"YH Lee","year":"2014","unstructured":"Lee YH, Suzer F, Thermann H (2014) Autologous matrix-induced chondrogenesis in the knee: a review. Cartilage 5(3):145\u2013153","journal-title":"Cartilage"},{"issue":"4","key":"5079_CR14","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.arthro.2014.11.018","volume":"31","author":"TS Lynch","year":"2015","unstructured":"Lynch TS, Patel RM, Benedick A, Amin NH, Jones MH, Miniaci A (2015) Systemic review of autogenous osteochondral transplant outcomes. Arthroscopy 31(4):746\u2013754","journal-title":"Arthroscopy"},{"key":"5079_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejrad.2005.08.007","volume":"57","author":"S Marlovits","year":"2006","unstructured":"Marlovits S, Singer P, Zeller P, Mandl I, Haller J, Trattnig S (2006) Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol 57:16\u201323","journal-title":"Eur J Radiol"},{"issue":"4","key":"5079_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/JSA.0b013e31818cdb82","volume":"16","author":"AG McNickle","year":"2008","unstructured":"McNickle AG, Provencher MT, Cole BJ (2008) Overview of existing cartilage repair technology. Sports Med Arthrosc 16(4):196\u2013201","journal-title":"Sports Med Arthrosc"},{"issue":"1","key":"5079_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/1947603515595837","volume":"7","author":"S Methot","year":"2016","unstructured":"Methot S, Changoor A, Tran-Khanh N, Hoemann CD, Stanish WD, Restrepo A, Shive MS, Buschmann MD (2016) Osteochondral biopsy analysis demonstrates that BST-CarGel treatment improves structural and cellular characteristics of cartilage repair tissue compared with microfracture. Cartilage 7(1):16\u201328","journal-title":"Cartilage"},{"issue":"1","key":"5079_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ejrad.2008.04.007","volume":"71","author":"SF Nemec","year":"2009","unstructured":"Nemec SF, Marlovits S, Trattnig S (2009) Persistent bone marrow edema after osteochondral autograft transplantation in the knee joint. Eur J Radiol 71(1):159\u2013163","journal-title":"Eur J Radiol"},{"issue":"4","key":"5079_CR19","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.arthro.2014.11.023","volume":"31","author":"S Oussedik","year":"2015","unstructured":"Oussedik S, Tsitskaris K, Parker D (2015) Treatment of articular cartilage lesions of the knee by microfracture or autologous chondrocyte implantation: a systematic review. Arthroscopy 31(4):732\u2013744","journal-title":"Arthroscopy"},{"issue":"6","key":"5079_CR20","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s00167-011-1655-1","volume":"20","author":"S Panseri","year":"2012","unstructured":"Panseri S, Russo A, Cunha C, Bondi A, Di Martino A, Patella S, Kon E (2012) Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration. Knee Surg Sports Traumatol Arthrosc 20(6):1182\u20131191","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"5079_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.arthro.2010.11.054","volume":"27","author":"KY Saw","year":"2011","unstructured":"Saw KY, Anz A, Merican S, Tay YG, Ragavanaidu K, Jee CS, McGuire DA (2011) Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic acid after arthroscopic subchondral drilling: a report of 5 cases with histology. Arthroscopy 27(4):493\u2013506","journal-title":"Arthroscopy"},{"issue":"18","key":"5079_CR22","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.2106\/JBJS.L.01345","volume":"95","author":"WD Stanish","year":"2013","unstructured":"Stanish WD, McCormack R, Forriol F, Mohtadi N, Pelet S, Desnoyers J, Restrepo A, Shive MS (2013) Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial. J Bone Joint Surg Am 95(18):1640\u20131650","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"5079_CR23","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s11999-011-2107-4","volume":"470","author":"A Siclari","year":"2012","unstructured":"Siclari A, Mascaro G, Gentili C, Cancedda R, Boux EA (2012) Cell-free scaffold-based cartilage repair provides improved function hyaline-like repair at one year. Clin Orthop Relat Res 470(3):910\u2013919","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"5079_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/1947603514562064","volume":"6","author":"MS Shive","year":"2015","unstructured":"Shive MS, Stanish WD, McCormack R, Forriol F, Mohtadi N, Pelet S, Desnoyers J, Methot S, Vehik K, Restrepo A (2015) BST-CarGel\u00ae treatment maintains cartilage repair superiority over microfracture at 5 years in a multicenter randomized controlled trial. Cartilage 6(2):62\u201372","journal-title":"Cartilage"},{"issue":"1","key":"5079_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.arthro.2016.06.035","volume":"33","author":"H Sofu","year":"2017","unstructured":"Sofu H, Kockara N, Oner A, Camurcu Y, Iss\u0131n A, Sahin V (2017) Results of hyaluronic acid-based cell-free scaffold application in combination with microfracture for the treatment of osteochondral lesions of the knee: 2-year comparative study. Arthroscopy 33(1):209\u2013216","journal-title":"Arthroscopy"},{"issue":"2","key":"5079_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ocl.2012.02.003","volume":"43","author":"F Vannini","year":"2012","unstructured":"Vannini F, Battaglia M, Buda R, Cavallo M, Giannini S (2012) \u201cOne step\u201d treatment of juvenile osteochondritis dessecans in the knee: clinical results and T2 mapping characterisation. Orthop Clin North Am 43(2):237\u2013244","journal-title":"Orthop Clin North Am"},{"issue":"3","key":"5079_CR27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1302\/0301-620X.97B3.34555","volume":"97","author":"P Verdonk","year":"2015","unstructured":"Verdonk P, Dhollander A, Almqvist KF, Verdonk R, Victor J (2015) Treatment of osteochondral lesions in the knee using a cell-free scaffold. Bone Jt J 97(3):318\u2013323","journal-title":"Bone Jt J"},{"key":"5079_CR28","first-page":"e663","volume":"6","author":"Y Villa","year":"2014","unstructured":"Villa Y, Rico J, Dalmau A, Chaques FJ, Asuncion J (2014) Treatment of osteochondral lesions of the talus with bone marrow stimulation and chitosan glycerol phosphate\/blood implants (BST-CarGel). Arthrosc Tech 6:e663\u2013e667","journal-title":"Arthrosc Tech"},{"issue":"12","key":"5079_CR29","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3928\/01477447-20141124-02","volume":"37","author":"AB Yanke","year":"2014","unstructured":"Yanke AB, Cole BJ (2014) Microfracture: dead or the future? Orthopedics 37(12):798\u2013800","journal-title":"Orthopedics"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-018-5079-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00167-018-5079-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-018-5079-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T04:17:14Z","timestamp":1751775434000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00167-018-5079-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["5079"],"URL":"https:\/\/doi.org\/10.1007\/s00167-018-5079-z","relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]},"assertion":[{"value":"12 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This\u00a0study was conducted in compliance with ethical standards\u00a0after having IRB approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}