{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:29:47Z","timestamp":1771504187482,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Deutsche Arthrose Hilfe e.V."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to compare the subjective ankle function within the first year following matrix\u2010induced bone marrow stimulation (M\u2010BMS) of patients with a solitary osteochondral lesion of the talus (OCLT) with and without concomitant chronic ankle instability (CAI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the German Cartilage Registry (KnorpelRegister DGOU) for 78 patients with a solitary OCLT and a follow\u2010up of at least 6\u00a0months were included. All patients received M\u2010BMS for OCLT treatment. The cohort was subdivided into patients with OCLT without CAI treated with M\u2010BMS alone (<jats:italic>n<\/jats:italic>\u2009=\u200940) and patients with OCLT and CAI treated with M\u2010BMS and additional ankle stabilisation (<jats:italic>n<\/jats:italic>\u2009=\u200938). The Foot and Ankle Ability Measure (FAAM), the Foot and Ankle Outcome Score (FAOS), and the Numeric Rating Scale for Pain (NRS) were used to assess patient\u2010reported outcomes (median (minimum\u2013maximum)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From preoperatively to 12\u00a0months postoperatively, patients with OCLT without CAI treated with M\u2010BMS alone had a significant improvement of all subscales in the FAAM [activity of daily living 64.3 (10\u2013100) to 88.1 (39\u2013100); sports 34.4 (0\u2013100) to 65.6 (13\u201394), functional activities of daily life 50 (0\u201390) to 80 (30\u2013100), functional sports 30 (0\u2013100) to 70 (5\u2013100)] and FAOS [pain 61.1 (8\u201394) to 86.1 (50\u2013100), symptoms 60.7 (18\u201396) to 76.8 (29\u2013100), activities of daily living 72.1 (24\u2013100) to 91.9 (68\u2013100), sport\/recreational activities 30.0 (0\u201370) to 62.5 (0\u201395), quality of life 31.3 (6\u201350) to 46.9 (19\u2013100)]. Within the first year, patients with OCLT and CAI treated with M\u2010BMS and ankle stabilisation also showed significant improvement in the FAAM [activity of daily living 68.8 (5\u201399) to 90.5 (45\u2013100); sports 32.8 (0\u201387.5) to 64.1 (0\u201394), functional activities of daily life 62.5 (25\u2013100) to 80 (60\u201390), functional sports 30 (0\u2013100) to 67.5 (0.95)] and the FAOS [pain 66.7 (28\u201392) to 87.5 (47\u2013100), symptoms 57.1 (29\u201396) to 78.6 (50\u2013100), activities of daily living 80.1 (25\u2013100) to 98.5 (59\u2013100), sport\/recreational activities 35.0 (0\u2013100) to 70.0 (0\u2013100), quality of life 25.0 (0\u201375) to 50.0 (19\u201394)]. The pain level decreased significantly in both groups. No significant difference was found between both groups regarding the subscales of FAAM, FAOS and the NRS 1 year postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improvements in subjective ankle function, daily life activities and sports activities were observed within the first year following M\u2010BMS. Our results suggest that preexisting and treated ankle instability did not compromise subjective outcome in patients treated with M\u2010BMS in the first postoperative year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-020-06172-5","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T02:08:22Z","timestamp":1596161302000},"page":"1187-1196","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preexisting and treated concomitant ankle instability does not compromise patient\u2010reported outcomes of solitary osteochondral lesions of the talus treated with matrix\u2010induced bone marrow stimulation in the first postoperative year: data from the German Cartilage Registry (KnorpelRegister DGOU)"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-4182","authenticated-orcid":false,"given":"Marc\u2010Daniel","family":"Ahrend","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Traumatology and Reconstructive Surgery BG Trauma Center T\u00fcbingen, Eberhard Karls University T\u00fcbingen Schnarrrenbergstr. 95 72076 T\u00fcbingen Germany"},{"name":"<!--<label>10<\/label>--> AO Research Institute Davos Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Aurich","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Department of Orthopaedics and Special Trauma Surgery Klinikum Mittleres Erzgebirge gGmbH Zschopau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Becher","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> International Center of Hip\u2010, Knee\u2010 and Foot Surgery, Sport Traumatology, ATOS Clinic Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atesch","family":"Ateschrang","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Traumatology and Reconstructive Surgery BG Trauma Center T\u00fcbingen, Eberhard Karls University T\u00fcbingen Schnarrrenbergstr. 95 72076 T\u00fcbingen Germany"},{"name":"<!--<label>2<\/label>--> Department of Orthopaedics and Trauma Surgery Gemeinschaftsklinikum Mittelrhein Ev. Stift St. Martin Koblenz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Schr\u00f6ter","sequence":"additional","affiliation":[{"name":"<!--<label>5<\/label>--> Department of Traumatology and Reconstructive Surgery Diakonie Klinikum GmbH Jung\u2010Stilling\u2010Krankenhaus Siegen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Walther","sequence":"additional","affiliation":[{"name":"<!--<label>6<\/label>--> Sch\u00f6n Klinik Munich Harlaching \u2013 FIFA Medical Centre of Excellence Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"<!--<label>6<\/label>--> Sch\u00f6n Klinik Munich Harlaching \u2013 FIFA Medical Centre of Excellence Munich Germany"},{"name":"<!--<label>7<\/label>--> Department of General, Trauma and Reconstructive Surgery, University Hospital LMU Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Plaass","sequence":"additional","affiliation":[{"name":"<!--<label>8<\/label>--> Department for Foot and Ankle surgery Orthopedic Clinic of the Hannover Medical School in DIAKOVERE Annastift Anna\u2010von\u2010Borries Strasse 1\u20107 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ettinger","sequence":"additional","affiliation":[{"name":"<!--<label>8<\/label>--> Department for Foot and Ankle surgery Orthopedic Clinic of the Hannover Medical School in DIAKOVERE Annastift Anna\u2010von\u2010Borries Strasse 1\u20107 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Zinser","sequence":"additional","affiliation":[{"name":"<!--<label>9<\/label>--> Department of Orthopaedics and Trauma Surgery St. Vinzenz Hospital Dinslaken Dinslaken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Traumatology and Reconstructive Surgery BG Trauma Center T\u00fcbingen, Eberhard Karls University T\u00fcbingen Schnarrrenbergstr. 95 72076 T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","unstructured":"AyyaswamyB SalimM SidaginamaleR ElsayedM KarpeP LimayeREarly to medium term outcomes of osteochondral lesions of the talus treated by autologous matrix induced chondrogenesis (AMIC).Foot Ankle Surg(2020)10.1016\/j.fas.2020.04.00832414700","DOI":"10.1016\/j.fas.2020.04.008"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508319050"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.09.030"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716687367"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509351556"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2018.05.006"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465020300031601"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010017\u20104774\u20105"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/107110079902001106"},{"key":"e_1_2_10_11_2","unstructured":"K\u00f6rnerD AteschrangA Schr\u00f6terS AurichM BecherC WaltherMet al. Concomitant ankle instability has a negative impact on the quality of life in patients with osteochondral lesions of the talus: data from the German Cartilage Registry (KnorpelRegister DGOU).Knee Surg Sports Traumatol Arthrosc(2020)10.1007\/s00167\u2010020\u201005954\u2010132737525"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010015\u20102988\u2010z"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1938640011416355"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100715581477"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010017\u20104591\u2010x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010018\u20105184\u2010z"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504271058"},{"key":"e_1_2_10_18_2","unstructured":"RothrauffBB MurawskiCD AngthongC BecherC NehrerS NiemeyerP et al. (2018)Scaffold\u2010based therapies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle.Foot Ankle Int 39. pp.41s\u201347s"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010017\u20104748\u20107"},{"key":"e_1_2_10_20_2","unstructured":"SripanichY DekeyserG SteadmanJ RungpraiC HallerJ SaltzmanCLet al. Limitations of accessibility of the talar dome with different open surgical approaches.Knee Surg Sports Traumatol Arthrosc(2020)10.1007\/s00167\u2010020\u201006113\u2010232596777"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354659302100120"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010016\u20104318\u20104"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2015.02.010"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513476671"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519841574"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2012.12.009"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516659643"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010014\u20101969\u20109"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-020-06172-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00167-020-06172-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-020-06172-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-020-06172-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:28:46Z","timestamp":1760866126000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-020-06172-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1007\/s00167-020-06172-5"],"URL":"https:\/\/doi.org\/10.1007\/s00167-020-06172-5","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"27 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"OG received reimbursement of speaker fees and travel expenses from Geistlich Pharma AG. CP is a consultant of Medartis. CP or his institution received personal or scientific support from the following companies: Implantcast, Medartis, Stryker, DePuySynthes, Arthrex, OPED, Albrecht and Synthelix. There is no relevant conflict of interest regarding this paper. All other authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The German Cartilage Registry is financially supported by the Deutsche Arthrose-Hilfe e.V. and the Stiftung Oskar-Helene-Heim.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The data used in this study were obtained from the <i>German Cartilage Registry (KnorpelRegister DGOU)<\/i>. Approval was given by the institutional review board (IRB) at every participating clinical centre. The identification number of the IRB of the study coordination centre at the University Hospital of Freiburg, Germany is B-F-2013-075#A1.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}