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The purpose of this study is to report (1) revision rate and causes, (2) clinical results based on patient report outcome measures (PROMs), and (3) radiological signs of implant dysfunction in patients with an uncemented TKA implanted with restricted KA (rKA), after a minimum follow\u2010up of 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included the first 100 consecutive uncemented cruciate retaining TKAs implanted between November 2015 and February 2018 by a single surgeon following rKA principles. At last follow\u2010up, all adverse events and PROMs assessed by WOMAC, KOOS, and FJS scores were documented. Radiographic evaluation was performed to identify signs of implant loosening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a mean follow\u2010up of 49\u00a0months (32, 60), no implant revision was performed for aseptic loosening. Three revisions were performed: one for malalignment, one for a deep infection, and one for instability. The mean WOMAC score was 20.1 (0\u201379, 21.3), the mean KOOS score was 71.5 (19.0\u201396.6, 19.8), and the mean FJS score was 65.9 (0\u2013100, 29.6). No radiological evidence of implant aseptic loosening or osteolysis was identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that in 99% of our cases, rKA combined with the tested cementless TKA implant allowed for adequate secondary fixation and good functional outcomes in the short term. Favourable mid\u2010 to long\u2010term implant survivorship is anticipated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-020-06427-1","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T08:02:42Z","timestamp":1610784162000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Restricted kinematic alignment leads to uncompromised osseointegration of cementless total knee arthroplasty"],"prefix":"10.1002","volume":"30","author":[{"given":"Guillaume","family":"Laforest","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Surgery Department H\u00f4pital Maisonneuve\u2010Rosemont, Universit\u00e9 de Montr\u00e9al 5415 Boul l\u2019Assomption H1T 2M4 Montreal QC 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