{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:14:48Z","timestamp":1786979688155,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to perform a systematic review of randomized controlled trials comparing the results of matrix\u2010induced chondrogenesis with other therapies for local chondral lesions of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search for randomized controlled trials (RCT) about matrix\u2010induced chondrogenesis for focal chondral lesions in the knee was performed according to the PRISMA guidelines. Data source was PubMed central, EMBASE and Google scholar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five articles could be included, whereas two originated from the same study group. Three studies compared matrix\u2010induced chondrogenesis to microfracture (MFx) only. One trial compared AMIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      to collagen\u2010covered autologous chondrocyte implantation (ACI\u2010C). One study assessed the improvements given by the combination of AMIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      with bone marrow aspirate concentrate (BMAC). In three studies, clinical improvements compared to baseline were seen at 2\u2010year postoperation, irrespective of the technique used. After 5 years, one trial showed better results for the AMIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group compared to MFx, including MRI defect filling. One study showed also good results after AMIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      with faster recovery for patients with AMIC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      \u2009+\u2009BMAC 12\u00a0months postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results of RCTs comparing matrix\u2010induced chondrogenesis with other treatment options showed that matrix\u2010induced chondrogenesis is a valid and safe cartilage repair option for small\u2010 to medium\u2010sized cartilage defects of the knee. This one\u2010stage surgical technique presents a good alternative for patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>I.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-021-06513-y","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T06:02:42Z","timestamp":1616220162000},"page":"4213-4222","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Matrix\u2010induced chondrogenesis is a valid and safe cartilage repair option for small\u2010 to medium\u2010sized cartilage defects of the knee: a systematic review"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-5914","authenticated-orcid":false,"given":"Katrin","family":"Karpinski","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> 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