{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:16:11Z","timestamp":1790403371493,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Partial meniscectomy is a common orthopedic procedure intended to improve knee pain and function in patients with irreparable meniscal tears. However, 6\u201325% of partial meniscectomy patients experience persistent knee pain after surgery. In this randomized controlled trial (RCT) involving subjects with knee pain following partial meniscectomy, it was hypothesized that treatment with a synthetic medial meniscus replacement (MMR) implant provides significantly greater improvements in knee pain and function compared to non\u2010surgical care alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, multicenter RCT, subjects with persistent knee pain following one or more previous partial meniscectomies were randomized to receive either MMR or non\u2010surgical care. This analysis evaluated the 1\u2010year outcomes of this 2\u2010year clinical trial. Patient\u2010reported knee pain, function, and quality of life were measured using nine separate patient\u2010reported outcomes. The primary outcomes were the pain subscale of the Knee injury and Osteoarthritis Outcome Score (KOOS) and the average of all five KOOS subscales (KOOS Overall). Treatment cessation was defined as permanent device removal in the MMR group and any surgical procedure to the index knee in the non\u2010surgical care group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treated subjects had a median age of 52 years old (range 30\u201369 years) and one or more previous partial meniscectomies at a median of 34\u00a0months (range 5\u2013430\u00a0months) before trial entry. Among 127 subjects treated with either MMR (<jats:italic>n<\/jats:italic>\u2009=\u200961) or non\u2010surgical care (<jats:italic>n<\/jats:italic>\u2009=\u200966), 11 withdrew from the trial or were lost to follow\u2010up (MMR, <jats:italic>n<\/jats:italic>\u2009=\u20090; non\u2010surgical care, <jats:italic>n<\/jats:italic>\u2009=\u200911). The magnitude of improvement from baseline to 1 year was significantly greater in subjects who received MMR in both primary outcomes of KOOS Pain (<jats:italic>P<\/jats:italic>\u2009=\u20090.013) and KOOS Overall (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). Treatment cessation was reported in 14.5% of non\u2010surgical care subjects and only 4.9% of MMR subjects (n.s.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with the synthetic MMR implant resulted in significantly greater improvements in knee pain, function, and quality of life at 1 year of follow\u2010up compared to treatment with non\u2010surgical care alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>I.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-021-06573-0","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T15:32:01Z","timestamp":1619019121000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of post\u2010meniscectomy knee symptoms with medial meniscus replacement results in greater pain reduction and functional improvement than non\u2010surgical care"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9709-6461","authenticated-orcid":false,"given":"Kenneth R.","family":"Zaslav","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Ortho Virginia, Virginia Commonwealth University 7858 Shrader Road 23294 Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Farr","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> OrthoIndy Greenwood IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Alfred","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> The Bone and Joint Center Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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JF reports research support from Episurf, Fidia Pharma, Moximed Inc, Novartis Inc, Samumed Inc, Vericel Inc, Zimmer Biomet, Organogenesis outside of this submitted work. Personal consulting fees, stocks, and\/or royalties from Moximed Inc, Vericel Inc, Arthrex, Depuy Syntheses Products Inc, Organogenesis, Biopoly LLC, Medshape Inc, OrthoRegnerative Technologies, Aesculap, Cartiheal, Cook Biotech Inc, JRF Ortho, ZKR Orthopedics Inc, and Regentis Biomaterials outside of the submitted work. Editorial Board for American Journal of Sports Medicine, Cartilage, and Journal of Knee Surgery outside of the submitted work. AG reports personal consulting fees from Moximed, Organogenesis, JRF, Smith and Nephew, and Vericel outside of the submitted work. MD reports salaried employee of Telos Partners, LLC, which received funding from Active Implants to support data analysis and technical writing related to the submitted work. EH reports personal consulting fees from Active Implants outside of the submitted work. CL reports personal fees from Joint Restoration Foundation, Sanumed, and Vericel outside of the submitted work. BM reports minority ownership in Boston Outpatient Surgical Suites and shareholder in Parcus Medical, LLC outside of the submitted work. The other authors report no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures involving human subjects performed in this study were approved by the Institutional Review Board at each site and were conducted in accordance with the principles of the Declaration of Helsinki and good clinical practice.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All subjects gave written informed consent before participation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}