{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:32:46Z","timestamp":1784640766551,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report second\u2010look arthroscopic assessment after all\u2010arthroscopic autologous chondrocyte implantation (ACI) for articular cartilage defects at the patella.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A second\u2010look arthroscopy after all\u2010arthroscopic ACI using chondrospheres<jats:sup>\u00ae<\/jats:sup> (ACT3D) was performed in 30 patients with 30 full\u2010thickness retropatellar cartilage defects. The mean time from ACI to second\u2010look arthroscopy was 14.9\u2009\u00b1\u200916.3 (6\u201371) months. The quality of cartilage regeneration was evaluated by the International Cartilage\u2010Repair Score (ICRS)\u2014Cartilage Repair Assessment (CRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven lesions (36.7%) were classified as CRA grade I (normal) and 19 lesions (63.3%) as grade II (nearly normal). Concerning the degree of defect repair, 25 lesions (83.3%) were repaired up to the height of the surrounding articular retropatellar cartilage. Five lesions (16.7%) showed 75% repair of defect depth. The border zone was completely integrated into the surrounding articular cartilage shoulder in 28 lesions (93.3%) and demarcated within 1\u00a0mm in 2 lesions (6.7%). Macroscopically and by probing, 12 lesions (40%) had intact smooth surface, 17 lesions (56.7%) had fibrillated surface and 1 lesion (3.3%) had small, scattered fissures. A negative correlation was found between the overall repair assessment score and the defect size (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u2212 0.430, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and between integration into border zone and defect size (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u2212 0.340, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). A positive correlation was found between macroscopic appearance and age (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u2009+\u20090.384, <jats:italic>p<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All\u2010arthroscopic ACI using chondrospheres<jats:sup>\u00ae<\/jats:sup> (ACT3D) for full\u2010thickness retropatellar articular cartilage defects proved to be reproducible and reliable. The advantage of the procedure is that it is minimal invasive. Arthroscopic second\u2010look demonstrated a high grade of normal or nearly normal cartilage regeneration. Although statistically significant differences were not observed, larger defect size and younger age may compromise the result of overall repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-021-06584-x","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T16:20:19Z","timestamp":1619281219000},"page":"1535-1542","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Good healing potential of patellar chondral defects after all\u2010arthroscopic autologous chondrocyte implantation with spheroids: a second\u2010look arthroscopic assessment"],"prefix":"10.1002","volume":"30","author":[{"given":"Yoshikazu","family":"Sumida","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> International Center for Orthopedics ATOS Hospital Heidelberg Bismarckstrasse 9\u201015 69115 Heidelberg Germany"},{"name":"<!--<label>2<\/label>--> Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University 1\u20102\u20103 Kasumi, Minami\u2010ku 734\u20108551 Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> International Center for Orthopedics ATOS Hospital Heidelberg Bismarckstrasse 9\u201015 69115 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Feil","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> International Center for Orthopedics ATOS Hospital Heidelberg Bismarckstrasse 9\u201015 69115 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Siebold","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> International Center for Orthopedics ATOS Hospital Heidelberg Bismarckstrasse 9\u201015 69115 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kirsch","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Institute for Anatomy and Cell Biology Ruprecht\u2010Karls University, INF 307 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Siebold","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> International Center for Orthopedics ATOS Hospital Heidelberg Bismarckstrasse 9\u201015 69115 Heidelberg Germany"},{"name":"<!--<label>3<\/label>--> Institute for Anatomy and Cell Biology Ruprecht\u2010Karls University, INF 307 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010013\u20102521\u20100"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623\u2010200300002\u201000008"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749\u20108063(97)90124\u20109"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119876618"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515574063"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517724761"},{"key":"e_1_2_8_8_2","unstructured":"EMA(2017)Spheroids of human autologous matrix\u2010associated chondrocytes.https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/spherox#product\u2010information\u2010section. 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