{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:28:53Z","timestamp":1771039733851,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008334","name":"Stiftung Oskar-Helene-Heim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Arthrosehilfe e.V."},{"DOI":"10.13039\/501100008334","name":"Stiftung Oskar-Helene-Heim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Both acute ruptures of the anterior cruciate ligament (ACL) as well as chronic ACL insufficiency show a high association with focal cartilage defects of the knee. However, the results after combined ACL reconstruction and cartilage repair are not well investigated. The aim of the present study was to investigate the short\u2010term outcomes after autologous chondrocyte implantation (ACI) in combination with ACL reconstruction and to compare the results with patients who underwent isolated ACI in ligament intact knees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who were registered in the German Cartilage Registry with ACI for focal cartilage defects in the knee joint in combination with ACL reconstruction and who completed the 24\u00a0month follow\u2010up were included in the study group. A matched\u2010pair procedure according to gender, defect location, defect size, and age was used to create a control group of patients with isolated ACI in ACL intact joints. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the numeric analog scale for pain (NAS) were used to assess the preoperative state as well as the clinical outcomes 12 and 24\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 patients were included in both the study group (age mean 33.3\u2009\u00b1\u2009SD 8.8 years) and the control group (33.6\u2009\u00b1\u20098.4 years) with a median defect size of 466 (25%\u201075% IQR 375\u2013600) mm<jats:sup>2<\/jats:sup> and 425 (IQR 375\u2013600) mm<jats:sup>2<\/jats:sup>, respectively. In comparison with the preoperative state (median 67, IQR 52\u201375), the study group showed a significant increase of the total KOOS after 12\u00a0months (78, IQR 70\u201386; <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and after 24\u00a0months (81, IQR 70\u201384; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The NAS for pain did not change significantly in the postoperative course. In comparison with the control group there was no significant difference for the total KOOS neither preoperative (control group median 67, IQR 52\u201373) nor at any postoperative time point (12\u00a0months: 82, IQR 67\u201393; 24\u00a0months: 81, IQR 71\u201391).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical short\u2010term outcomes after ACI at the knee joint in combination with ACL reconstruction are good and similar to the results after isolated ACI in ligament intact knees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-021-06764-9","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T11:58:27Z","timestamp":1633867107000},"page":"3249-3257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short\u2010term results in comparison with isolated cartilage repair in ligament intact joints"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-5722","authenticated-orcid":false,"given":"Julian","family":"Mehl","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar Technical University Ismaninger Strasse 22 81675 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Feucht","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Orthopaedic Surgery Paulinenhilfe, Diakonieklinikum Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Achtnich","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar Technical University Ismaninger Strasse 22 81675 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas B.","family":"Imhoff","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar Technical University Ismaninger Strasse 22 81675 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> OCM Clinic Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Angele","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Department for Traumatology University Hospital Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Zinser","sequence":"additional","affiliation":[{"name":"<!--<label>5<\/label>--> Department of Orthopaedic Surgery and Traumatology St. Vinzenz Hospital Dinslaken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunter","family":"Spahn","sequence":"additional","affiliation":[{"name":"<!--<label>6<\/label>--> Center of Trauma and Orthopaedic Surgery Eisenach Jena University Hospital Eisenach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Loer","sequence":"additional","affiliation":[{"name":"<!--<label>7<\/label>--> Orthopaedie in Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heino","family":"Kniffler","sequence":"additional","affiliation":[{"name":"<!--<label>8<\/label>--> Orthopaedische Praxisklinik Kelkheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Schauf","sequence":"additional","affiliation":[{"name":"<!--<label>9<\/label>--> Gelenkzentrum Bergischland Remscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schmitt","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar Technical University Ismaninger Strasse 22 81675 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514548160"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010005\u20100025\u20103"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010012\u20101637\u2010x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623\u2010200300002\u201000008"},{"key":"e_1_2_8_6_2","unstructured":"BurgerD FeuchtM MuenchLN ForkelP ImhoffAB MehlJGood clinical outcomes after patellar cartilage repair with no evidence for inferior results in complex cases with the need for additional patellofemoral realignment procedures: a systematic review.Knee Surg Sports Traumatol Arthrosc(2021)10.1007\/s00167\u201000021\u201006728\u2010z34510221"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21148"},{"key":"e_1_2_8_8_2","first-page":"363546521993818","article-title":"Higher incidence of radiographic posttraumatic osteoarthritis with transtibial femoral tunnel positioning compared with anteromedial femoral tunnel positioning during anterior cruciate ligament reconstruction: a systematic review and meta\u2010analysis.","volume":"2021","author":"Cinque ME","year":"2021","journal-title":"Am J Sports Med"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514525910"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105413.152442"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504265006"},{"key":"e_1_2_8_12_2","first-page":"194760352098234","article-title":"Comparison of clinical outcome following cartilage repair for patients with underlying varus deformity with or without additional high tibial osteotomy: a propensity score\u2010matched study based on the German Cartilage Registry (KnorpelRegister DGOU).","volume":"2020","author":"Faber S","year":"2020","journal-title":"Cartilage"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010016\u20104097\u2010y"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010011\u20101818\u20100"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509352157"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211010487"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010018\u20105321\u20108"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010003\u20100422\u20103"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010019\u201003128\u20104"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119854442"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101383222"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.03.009"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516682492"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967117693591"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511423380"},{"key":"e_1_2_8_26_2","first-page":"363546521103614","article-title":"Relationship between timing of anterior cruciate ligament reconstruction and chondral injuries: a systematic review and meta\u2010analysis.","volume":"2021","author":"Prodromidis AD","year":"2021","journal-title":"Am J Sports Med"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20101\u201064"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516629944"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101383081"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010020\u201006365\u2010y"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518767636"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.10.008"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2015.08.015"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.06.034"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-021-06764-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00167-021-06764-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-021-06764-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-021-06764-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:33:26Z","timestamp":1760877206000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-021-06764-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,9]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1007\/s00167-021-06764-9"],"URL":"https:\/\/doi.org\/10.1007\/s00167-021-06764-9","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,9]]},"assertion":[{"value":"13 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"P.A. reports consulting for Arthrex and Aesculap. All other authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The German Cartilage Registry is conducted in accordance with the 1964 Declaration of Helsinki and registered at germanctr.de (DRKS00005617). The registration of data was approved by the local ethics committees of every participating institution. Primary approval was given by the ethics committee at the University of Freiburg (No. 520\/14). Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}