{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T09:55:47Z","timestamp":1780653347724,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Existing evidence estimates a twofold risk of venous thromboembolisms (VTEs) if tourniquet is applied during total knee arthroplasties (TKAs). However, this estimate relies on multiple trials with a low number of patients analyzing VTEs as a secondary outcome. We hypothesized that tourniquet\u2010use increases the risk of symptomatic VTE within 90\u00a0days of contemporary primary TKA and aimed to use the extensive Danish healthcare registries to quantify this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively collected registry data from Danish patients receiving primary TKAs between 2014 and 2018 were included in the study. Patients were divided by tourniquet\u2010use during surgery. By merging information from four nationwide registries, the study included 44 baseline characteristics with the potential to confound the association between tourniquet\u2010use and VTE. Incidence rate and odds ratios were used to compare the risk of VTE within 90\u00a0days of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>19,804 patients of whom 10,111 (51%) were operated with tourniquet and 9693 (49%) without were included. The mean age (SD) was 70 (9) in both groups and 62% were females in the tourniquet group compared with 61% in the no tourniquet group. The groups were similarly comparable across all other baseline characteristics except type of post\u2010operative thromboprophylaxis, type of anaesthesia, implant fixation, and year of surgery. The 90\u2010days incidence of VTE was 0.77% (95% CI 0.60\u20130.94) in the tourniquet group compared with 1.10% (95% CI 0.90\u20131.31) in the no tourniquet group. Following adjustment for the unbalanced confounders, the odds ratio for VTE was 0.77 (95% CI 0.54\u20131.10) associated with tourniquet\u2010use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In contemporary TKAs the rate of VTE within 90\u00a0days is low and not significant altered by tourniquet\u2010use. Thus, tourniquet can safely be applied during primary TKA\u2010surgery without jeopardizing the risk of postoperative VTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>II\u2014prospective cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-06965-w","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T09:18:10Z","timestamp":1650532690000},"page":"883-891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The use of tourniquet in primary total knee arthroplasty does not increase the risk of venous thromboembolism within 90\u00a0days of surgery: a Danish nationwide cohort study of 19,804 patients"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-8266","authenticated-orcid":false,"given":"Anders","family":"El\u2010Galaly","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic Surgery Aarhus University Hospital Palle Juul\u2010Jensens Blvd. 99 8200 Aarhus Denmark"},{"name":"<!--<label>2<\/label>--> Interdisciplinary Orthopaedics Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette Tarp","family":"Hansen","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"},{"name":"<!--<label>4<\/label>--> Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kappel","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Interdisciplinary Orthopaedics Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_11_2_2","first-page":"CD012874","article-title":"Tourniquet use for knee replacement surgery","volume":"12","author":"Ahmed I","year":"2020","journal-title":"Cochrane database Syst Rev"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.103B.BJJ\u20102020\u20101926.R1"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/03610910902859574"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.329"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3414\/ME17\u201001\u20100051"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010019\u20101422\u20104"},{"key":"e_1_2_11_8_2","unstructured":"Danish Knee Arthroplasty RegistryAnnual Report 2021.https:\/\/www.sundhed.dk\/content\/cms\/99\/4699_dkr_aarsrapport_2021.pdf. Accessed 12 Jan 2022"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.05.058"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086\u2010198911000\u201000004"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102013\u2010003965"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.1841"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010016\u20104208\u20109"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010019\u201005617\u2010w"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15132"},{"key":"e_1_2_11_16_2","first-page":"1","article-title":"Multicollinearity in regression analyses conducted in epidemiologic studies","volume":"06","author":"P. Vatcheva K, Lee M,","year":"2016","journal-title":"Epidemiol Open Access"},{"key":"e_1_2_11_17_2","first-page":"798","article-title":"Data resource profile: the Danish national prescription registry","volume":"46","author":"Potteg\u00e5rd A","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7275.1493"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13518"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010014\u20109930\u20103"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S179083"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.018"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010012832"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010021\u201002366\u2010w"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010014\u20102056\u2010y"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u2010799X\u20109\u201013"},{"key":"e_1_2_11_29_2","unstructured":"(2014)The Danish council for the use of expensive hospital medicines\u2014thromboprophylaxis in TKA\/THA surgery.https:\/\/rads.dk\/media\/2084\/210514\u2010baggrundsnotat\u2010tromboseprofylakse.pdf. 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