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Patient\u2019s subjective clinical outcomes including VAS, IKDC, Lysholm and Tegner scores as well as muscle strength measures were compared. Joint degeneration was evaluated by both radiographs to assess joint space width narrowing, Kellegren\u2013Lawrence (KL) grade and MRI with T2\u00a0mapping sequences to quantitatively analyze both cartilage and meniscal allograft degeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 10.8 years (range 10\u201314 years). The IKDC (IM vs DE, 89.8 vs 80.9, n.s.) and Lysholm scores (IM vs DE, 87.7 vs 78.0, n.s.) were close in two groups, while the IM group showed slightly lower VAS (IM vs DE, 0.2 vs 1.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.031), higher Tegner score (IM vs DE, 7 vs 3.5 <jats:italic>p<\/jats:italic>\u2009=\u20090.021) and better quadriceps muscle strength. The IM group had less joint space narrowing (IM vs DE, 0.35\u00a0mm vs 0.71\u00a0mm, n.s.), less KL grade progression (IM vs DE, 0.6 vs 1.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.041) on radiographs and less chondral lesions development on MRIs (Cartilage Degeneration Index, IM vs DE, 252 vs 2038, <jats:italic>p<\/jats:italic>\u2009=\u20090.025). All meniscal grafts exhibited degeneration by showing grade 3 signal on MRI, and 4 (4\/9) in the IM group and 8 (8\/10) cases in the DE group. The T2 value of cartilage and meniscal allograft in the IM group was close to that of the healthy control and was significantly lower than that of the DE group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to the conventional delayed MAT, the immediate MAT achieved better cartilage and meniscus protection in the long\u2010term, while its superiority in patient\u2010reported outcomes was limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-06982-9","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T15:04:38Z","timestamp":1651158278000},"page":"3708-3717","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The immediate meniscal allograft transplantation achieved better chondroprotection and less meniscus degeneration than the conventional delayed transplantation in the long\u2010term"],"prefix":"10.1002","volume":"30","author":[{"given":"Ding\u2010yu","family":"Wang","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Sports Medicine Department, Beijing Key Laboratory of Sports Injuries Peking University Third Hospital 49 North Garden Rd., Haidian District 100191 Beijing People\u2019s Republic of China"},{"name":"<!--<label>2<\/label>--> Institute of Sports Medicine of Peking University 100191 Beijing People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra A.","family":"Lee","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Department of Orthopedic Surgery, Sports Medicine and Arthroscopy University of California at Davis 95816 Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sports Medicine Department, Beijing Key Laboratory of Sports Injuries Peking University Third Hospital 49 North Garden Rd., Haidian District 100191 Beijing People\u2019s Republic of China"},{"name":"<!--<label>2<\/label>--> Institute of Sports Medicine of Peking University 100191 Beijing People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010zhang","family":"Li","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sports Medicine Department, Beijing Key Laboratory of Sports Injuries Peking University Third Hospital 49 North Garden Rd., Haidian District 100191 Beijing People\u2019s Republic of China"},{"name":"<!--<label>2<\/label>--> Institute of Sports Medicine of Peking University 100191 Beijing People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010yu","family":"Meng","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sports Medicine Department, Beijing Key Laboratory of Sports Injuries Peking University Third Hospital 49 North Garden Rd., Haidian District 100191 Beijing People\u2019s Republic of China"},{"name":"<!--<label>2<\/label>--> Institute of Sports Medicine of Peking University 100191 Beijing People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sports Medicine Department, Beijing Key Laboratory of Sports Injuries Peking University Third Hospital 49 North Garden Rd., Haidian District 100191 Beijing People\u2019s Republic of China"},{"name":"<!--<label>2<\/label>--> Institute of Sports Medicine of Peking University 100191 Beijing People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-7017","authenticated-orcid":false,"given":"Jia\u2010kuo","family":"Yu","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Sports 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and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of our hospital approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of their data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}