{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:33:26Z","timestamp":1787103206448,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004702","name":"Universit\u00e0 degli Studi di Genova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004702","name":"Universit\u00e0 degli Studi di Genova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to assess the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients\u2019 pre\u2010treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective Cohort Study Level II multicentric trial, consecutive patients with a diagnosis of early\/mild osteoarthritis and failure of previous conservative measures were enrolled to undergo diagnostic arthroscopy and a single MFAT injection. Patients were assessed with repeated scoring systems at baseline, 6\u00a0months, and 12\u00a0months after surgery. The demographic features, the arthroscopic findings, the immunophenotype of injected tissue and the histologic examination of synovia of failed patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 91 patients showed a significant improvement in Lysholm, WOMAC scores at 1\u2010year follow\u2010up (p\u2009&lt;\u20090.001). A significant decrease in VAS score was observed, while a significant improvement of measured flexion angle was registered at 1 year (p\u2009&lt;\u20090.001). No major complications were reported.<\/jats:p><jats:p>Age and synovitis were identified as significant factors influencing the clinical outcome (p\u2009&lt;\u20090.05). Body mass index, previous or concomitant procedures, and specific cartilage defects had no influence. The mean number of injected adipose tissue\u2010derived mesenchymal stem cells seem not to correlate with the clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MFAT is effective in reducing pain when used with a single dose injection in early\/mild OA of the knee, without major complications. Age over 60 and synovitis may be predictive for persistent pain at one year and should be considered before indications.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-07139-4","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T03:02:41Z","timestamp":1662778961000},"page":"3655-3664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-0327","authenticated-orcid":false,"given":"R.","family":"Ferracini","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"},{"name":"<!--<label>2<\/label>--> Ospedale Koelliker Corso Galileo Ferraris 247\/255 10134 Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alessio\u2010Mazzola","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> IRCCS Ospedale San Raffaele, Orthopaedic and Trauma Unit Via Olgettina 60 20132 Milan Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sonzogni","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stambazzi","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ursino","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Roato","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Department of Surgical Sciences, Bone and Dental Bioengineering Laboratory CIR\u2010Dental School, University of Turin via Nizza 230 10126 Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mussano","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Department of Surgical Sciences, Bone and Dental Bioengineering Laboratory CIR\u2010Dental School, University of Turin via Nizza 230 10126 Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bistolfi","sequence":"additional","affiliation":[{"name":"<!--<label>5<\/label>--> Orthopaedic and Traumatology Cardinal Massaia Hospital Corso Dante 202 14100 Asti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Furlan","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Godio","sequence":"additional","affiliation":[{"name":"<!--<label>6<\/label>--> First University Service Pathologic Anatomy, Azienda Ospedaliero\u2010Universitaria Citt\u00e0 Della Salute Corso Bramante 88 10126 Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Alotto","sequence":"additional","affiliation":[{"name":"<!--<label>7<\/label>--> Department of General Surgery and Special Surgery Burns Center Unit, Unit of Skin Bank Via Zuretti 29 10126 Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Formica","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Surgical Sciences University of Genova Largo Rosanna Benzi 10 16134 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,10]]},"reference":[{"issue":"25","key":"e_1_2_9_2_2","first-page":"101773","article-title":"Knee intra\u2010articular administration of stromal vascular fraction obtained from adipose tissue: A systematic review J Clin Orthop","volume":"22","author":"Aletto C","year":"2022","journal-title":"Trauma"},{"key":"e_1_2_9_3_2","unstructured":"BastosR MathiasM AndradeR AmaralRJFC Schott BalduinoVet al. 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All patients gave their written informed consent to participate in the study, which followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines and checklist.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}