{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:56:53Z","timestamp":1783749413343,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ATRO Medical BV"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this first\u2010in\u2010human study was to evaluate the effect of a polycarbonate anatomical meniscus prosthesis system, including the surgical procedure, on knee pain and describe potential adverse events in patients with post\u2010meniscectomy pain syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with post\u2010meniscectomy pain syndrome and limited underlying cartilage damage were enrolled in the study. Five received a medial polycarbonate urethane meniscus prosthesis which was clicked onto 2 titanium screws fixated at the native horn attachments on the tibia. The KOOS score was planned to be collected at baseline and at 3, 6, 12 and 24\u00a0months following the intervention including radiographs at 6, 12 and 24\u00a0months. MRI scans were repeated after 12 and 24\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The surgical technique to select an appropriately sized implant and correct positioning of the fixation screws and meniscus prosthesis onto the tibia was demonstrated to be feasible and reproducible. Inclusion stopped after 5 patients because of serious adverse device\u2010related events. All patients reported knee joint stiffness and slight effusion in their knee at 6\u00a0months follow\u2010up. In 3 patients the implant was removed because of implant failure and in 1 patient the implant was removed because of persistent pain and extension limitation. In none of the patients did the KOOS score improve in the first 6\u00a0months after surgery. However, in the patient who still has the implant in situ, PROMs started to improve 1 year after surgery and this improvement continued through 2 years of follow\u2010up. The KOOS Pain, symptoms and ADL were close to the maximal 100 points. KOOS QoL and sport did improve but remained suboptimal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This first version of the meniscus prosthesis led to impaired knee function and failed in four out of five patients. The patients where the prosthesis was removed were salvable and the PROMs returned to pre\u2010study levels. The results in the patient where the device is still in place are promising.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level II.\n<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-07205-x","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T22:02:36Z","timestamp":1667772156000},"page":"2526-2533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The first\u2010generation anatomical medial meniscus prosthesis led to unsatisfactory results: a first\u2010in\u2010human study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-0550","authenticated-orcid":false,"given":"T. G.","family":"van Tienen","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Radboud University Medical Centre Geert Grooteplein Zuid 10 6525 GA Nijmegen The Netherlands"},{"name":"<!--<label>2<\/label>--> ATRO Medical BV Liessentstraat 9\u2010A 5405 AH Uden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"van Minnen","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> ATRO Medical BV Liessentstraat 9\u2010A 5405 AH Uden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Defoort","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Sint Maartenskliniek Nijmegen Hengstdal 3 6574 NA Ubbergen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Emans","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Joint\u2010Preserving Clinic, Department of Orthopaedic Surgery Maastricht University Medical Centre P. Debyelaan 25 6229 HX Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A. W.","family":"van de Groes","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Radboud University Medical Centre Geert Grooteplein Zuid 10 6525 GA Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Verdonschot","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Radboud University Medical Centre Geert Grooteplein Zuid 10 6525 GA Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Jutten","sequence":"additional","affiliation":[{"name":"<!--<label>4<\/label>--> Joint\u2010Preserving Clinic, Department of Orthopaedic Surgery Maastricht University Medical Centre P. Debyelaan 25 6229 HX Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W. E.","family":"Pikaart","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> ATRO Medical BV Liessentstraat 9\u2010A 5405 AH Uden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J. C.","family":"Heesterbeek","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Sint Maartenskliniek Nijmegen Hengstdal 3 6574 NA Ubbergen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.12.050"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2014.07.001"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101695043"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010020\u201006218\u20108"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.09.043"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.02.034"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010018\u20100892\u20100"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jisakos\u20102020\u2010000600"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.06.036"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2017.02.012"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2015.06.075"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967120952414"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40634\u2010022\u201000531\u20106"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20101\u201064"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.08.021"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520916727"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12223"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010015\u20103632\u20106"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517713687"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010020\u201006276\u2010y"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211054022"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-022-07205-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00167-022-07205-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-022-07205-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-022-07205-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:10:48Z","timestamp":1760883048000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-022-07205-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1007\/s00167-022-07205-x"],"URL":"https:\/\/doi.org\/10.1007\/s00167-022-07205-x","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"6 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"BvM is employed at ATRO Medical BV. TvT receives a management fee from ATRO Medical BV. BvM and TvT own stocks in ATRO Medical BV. BvM, RP and TvT are inventors of applicable patents but have no ownership.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local medical ethical review board (METC Arnhem-Nijmegen number: 2017\u20133988) and registered in the Dutch Trial Register (NTR: NL75393.000.21).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained for each patient in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}