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Current available data from patients reported outcome measures (PROMs) and complications were collected, analyzed, and discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review was conducted according to the PRISMA guidelines. The following databases were accessed in May 2022: PubMed, Google scholar, Embase, and Scopus. All the clinical studies investigating the efficacy of ACI to manage chondral defects of the knee in skeletally immature patients were accessed. Articles treating patients with surgical procedures other than ACI were not eligible, nor were studies with a follow\u2010up shorter than 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 9 studies (251 procedures) were collected. 32% (80 of 251) of patients were females. The mean length of follow\u2010up was 44.2\u2009\u00b1\u200929.4 (range, 12\u2013115) months. The mean age of the patients was 16.4\u2009\u00b1\u20090.7 (range, 15\u201317) years. The Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Document Committee (IKDC) increased of\u2009+\u200941.9\/100 (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) and\u2009+\u200933.2\/100 (<jats:italic>P<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.0001) points, respectively. The Lysholm Knee Score improved of\u2009+\u200920.6\/100 (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) points. The Visual Analogue Scale (VAS) for pain reduced of \u2212 3.6\/10 (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) points. The Tegner scale did not show any statistically significant improvement from baseline to follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u2009n.s.). The rate of graft hypertrophy was 12.5% (5 of 40 patients), and the rate of failure 5.6% (8 of 142 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACI for chondral defects of the knee is effective to improve PROMs in skeletally immature patients. The safety profile of ACI still remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-07212-y","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T14:08:36Z","timestamp":1667484516000},"page":"2518-2525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-1221","authenticated-orcid":false,"given":"Filippo","family":"Migliorini","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic, Trauma, and Reconstructive Surgery RWTH University Hospital 52074 Aachen Germany"},{"name":"<!--<label>6<\/label>--> Department of Orthopedics and Trauma Surgery Eifelklinik St. Brigida 52152 Simmerath Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Eschweiler","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic, Trauma, and Reconstructive Surgery RWTH University Hospital 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Prinz","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Department of Ophthalmology RWTH University Hospital 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian David","family":"Weber","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic, Trauma, and Reconstructive Surgery RWTH University Hospital 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf Krister","family":"Hofmann","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic, Trauma, and Reconstructive Surgery RWTH University Hospital 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedic, Trauma, and Reconstructive Surgery RWTH University Hospital 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Department of Medicine, Surgery and Dentistry University of Salerno 84081 Baronissi SA Italy"},{"name":"<!--<label>4<\/label>--> School of Pharmacy and Bioengineering, Faculty of Medicine Keele University ST4 7QB Stoke On Trent England"},{"name":"<!--<label>5<\/label>--> Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital Queen Mary University of London, E1 4DG London England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","unstructured":"AgarwallaA LiuJN GarciaGH GowdAK PuzzitielloRN YankeABet al. 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