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This prospective cohort study aimed to assess the clinical evolution of the FIRST<jats:sup>\u00ae<\/jats:sup> prosthesis <jats:italic>(Symbios Orthop\u00e9die<\/jats:italic>, Yverdon, CH), the earliest prosthesis with this particular design. It was hypothesized that the primary outcomes, evaluating pain, stiffness, function and stability, would improve following arthroplasty and remain improved during the follow\u2010up period of 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients programmed for a total knee arthroplasty using a FIRST<jats:sup>\u00ae<\/jats:sup> prosthesis at our university hospital between 2006 and 2008 were invited to participate. Study knees were evaluated pre\u2010operatively as well as one, five and ten years post\u2010operatively. Patients filled out questionnaires at each evaluation point and had a radiographic assessment at the five\u2010year and ten\u2010year follow\u2010ups. Primary outcomes were the total, pain, stiffness and function measures of the Western Ontario and McMaster Universities Osteoarthritis questionnaire (WOMAC) and the knee and function measures of the Knee Society Score (KSS). Friedman and Wilcoxon\u2019s rank\u2010sum tests were used to compare measures across time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hundred and twenty four prostheses were included (baseline demographics: 69.9\u2009\u00b1\u20098.3 years old, 28.1\u2009\u00b1\u20094.3\u00a0kg\/m<jats:sup>2<\/jats:sup>, 54% male) and 68 could be followed during ten years. Five prostheses underwent a revision. All other prostheses lost at follow\u2010up were lost for reasons unrelated to the prosthesis. All primary measures reported statistically and clinically significant improvements between baseline and the three follow\u2010up evaluations. Statistically significant improvements at the three follow\u2010up evaluations were also observed for most secondary measures. There was no implant loosening. At ten\u2010year follow\u2010up, radiolucent lines were observed in 2.9% femoral implants and 1.5% tibial implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The positive results observed in all domains of assessment and the small revision rate demonstrated an effective functioning of the FIRST<jats:sup>\u00ae<\/jats:sup> prosthesis during the ten\u2010year follow\u2010up period. The results, globally similar to those previously published for other prosthesis designs, encourage the development of assistive methods to select the most appropriate designs on an individual basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>IV, prospective cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-022-07216-8","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T08:02:30Z","timestamp":1667721750000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ten\u2010year follow\u2010up of a total knee prosthesis combining multi\u2010radius, ultra\u2010congruency, posterior\u2010stabilization and mobile\u2010bearing insert shows long\u2010lasting clinically relevant improvements in pain, stiffness, function and stability"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3997-1616","authenticated-orcid":false,"given":"Killian","family":"Cosendey","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Swiss BioMotion Lab, Department of Musculoskeletal Medicine Lausanne University Hospital and University of Lausanne CH\u20101011 Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Eudier","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Service of Orthopaedics and Traumatology Broye Intercantonal Hospital Payerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Fleury","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Operational Unit, Department of Musculoskeletal Medicine Lausanne University Hospital and University of Lausanne Lausanne 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