{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:58:54Z","timestamp":1793948334036,"version":"4.8.0"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Fundaci\u00f3n Garc\u00eda Cugat"},{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P18-RTJ-1956"],"award-info":[{"award-number":["P18-RTJ-1956"]}],"id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Articular cartilage is vulnerable to multiple types of damage and it has limited reparative and regenerative capacities due to its absence of vascularity. Although a large number of therapeutic strategies exist to treat chondral defects, they have some limitations, such as fibrocartilage formation. Therefore, the goal of the present study was to evaluate the chondrogenic regenerative properties of an autologous\u2010made matrix of particulated cartilage and platelet\u2010rich plasma (PACI\u2009+\u2009PRP) implantation for the treatment of full\u2010thickness chondral defects in sheep.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A full\u2010thickness 8\u00a0mm diameter cartilage defect was created in the weight\u2010bearing area of the medial femoral condyle in both knees of 16 sheep. The right knees of all animals were treated with particulated autograft cartilage implantation and platelet\u2010rich plasma, while the left knees were injected with Ringer\u2019s lactate solution or hyaluronic acid. The sheep were killed 9 or 18\u00a0months after surgery. Macroscopic evaluations were performed using three different scoring systems, and histopathological evaluations were performed using a modified scoring system based on different scoring systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PACI\u2009+\u2009PRP groups showed statistically significant differences in the percentage of defect repair and chondrocytes in the newly formed cartilage tissue at 18\u00a0months compared to 9\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that macroscopic appearance, histological structure and chondrocyte repair were improved when using PACI\u2009+\u2009PRP treatment for chondral defects, producing an outcome similar to the surrounding healthy cartilage. PACI\u2009+\u2009PRP is a totally autologous, easy, and unexpensive treatment that can be performed in one\u2010step procedure and is useful as a therapeutic option for knee chondral defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-022-07295-7","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:03:13Z","timestamp":1672790593000},"page":"2944-2955","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Particulate cartilage and platelet\u2010rich plasma treatment for knee chondral defects in sheep"],"prefix":"10.1002","volume":"31","author":[{"given":"Lourdes","family":"Alcaide\u2010Ruggiero","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. Facultad de Veterinaria Universidad de C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"<!--<label>2<\/label>--> Fundaci\u00f3n Garc\u00eda Cugat para Investigaci\u00f3n Biom\u00e9dica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-7388","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Molina\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda. UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Morgaz","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. Facultad de Veterinaria Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Andr\u00e9s","family":"Fern\u00e1ndez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. Facultad de Veterinaria Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Granados","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. Facultad de Veterinaria Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Navarrete\u2010Calvo","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. Facultad de Veterinaria Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"<!--<label>3<\/label>--> Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda. UIC Zoonosis y Enfermedades Emergentes ENZOEM Universidad de C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setefilla","family":"Quir\u00f3s\u2010Carmona","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Departamento de Medicina y Cirug\u00eda Animal. 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August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experimental protocols were approved by Bioethical Committee on Animal Research of the Regional Government of Andalusia (Junta de Andaluc\u00eda 12\/06\/2016\/109-reference SSA\/SIS\/MD\/jv) and conducted in accordance to the protection of animals utilised for scientific purposes (Directive 2010\/63\/UE, Decision 2020\/569\/UE and RD 1386\/2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}