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MME commonly occurs in conjunction with osteoarthritis (OA) or medial meniscal tears (MMT). However, factors associated with concomitant MME in patients with OA or MMT have not been systematically reviewed. This study aims to perform a systematic review and meta\u2010analysis to identify factors associated with concomitant MME in OA or MMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The systematic review of the literature was performed according to PRISMA. A literature search was conducted in 4 databases. All original human studies that reported the available evidence on factors associated with concomitant MME in patients with OA or MMT were included. Pooled binary variables were analyzed by odds ratios (OR) and 95% CIs, and pooled continuous variables were evaluated by mean difference (MD) and 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies on OA (5993 patients) and eight studies on MMT (872 patients) met the inclusion criteria. The overall pooled incidence of MME was 43% (95% CI, 37\u201350%) for OA, 61% (95% CI 43\u201377%) for MMT, and 85% (95% CI 72\u201394%) for medial meniscal root tears (MMRT). For the population with OA, Factors significantly associated with MME included radiographic OA [OR 4.24; 95% CI 3.07\u20135.84; P\u2009&lt;\u20090.0001], bone marrow lesions [OR, 3.35; 95% CI 1.61\u20136.99; P\u2009=\u20090.0013], cartilage damage [OR, 3.25; 95% CI 1.60\u20136.61; P\u2009=\u20090.0011], and higher body mass index (BMI) [MD, 1.81; 95% CI 1.15\u20132.48; P\u2009&lt;\u20090.0001]. Factors strongly associated with increased risk of MME for MMT included medial meniscal root [OR, 8.39; 95% CI 2.84\u201324.82; P\u2009&lt;\u20090.0001] and radial tears [OR, 2.64; 95% CI 1.18\u20135.92; P\u2009&lt;\u20090.0001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiographic OA, bone marrow lesions, cartilage damage, and higher BMI were significantly associated with concomitant MME with OA. Furthermore, medial meniscal root and radial tears were significantly associated with an increased risk of MME in patients with MMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-023-07418-8","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:02:12Z","timestamp":1682467332000},"page":"3420-3433","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Radiographic OA, bone marrow lesions, higher body mass index and medial meniscal root tears are significantly associated with medial meniscus extrusion with OA or medial meniscal tears: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Hongwei","family":"Zhan","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedics, Orthopaedic Clinical Research Center of Gansu Province, Intelligent Orthopaedic Industry Technology Center of Gansu Province Lanzhou University Second Hospital No. 82 Cuiyingmen, Chengguan District 730000 Lanzhou Gansu People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcheng","family":"Liu","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Department of Orthopaedics, Orthopaedic Clinical Research Center of Gansu Province, Intelligent Orthopaedic Industry Technology Center of Gansu Province Lanzhou University Second Hospital No. 82 Cuiyingmen, Chengguan District 730000 Lanzhou Gansu People\u2019s Republic of 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On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval from the institutional ethics committee was not required for this review article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study informed consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}