{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:58:10Z","timestamp":1790420290365,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy of applying a combination of intrameniscal and intraarticular infiltrations of Platelet\u2010Rich Plasma (PRP) in patients with meniscal tears, analyzing its failure rate and clinical evolution, as well as factors that may influence the positive response to this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and ninety\u2010two cases out of 696\u00a0met the inclusion criteria and were included in this work. Survival and patient\u2010reported outcome measure (PROM) were collected and analyzed. Survival rate was defined as the percentage of patients who did not undergo meniscus surgery during their follow\u2010up time. Patients were asked to complete the Knee injury and Osteoarthritis Outcome Score (KOOS) at baseline, 6\u00a0months and 18\u00a0months. Other patient\u2010 and pathology\u2010related variables were collected. Blood and PRP samples were randomly tested as a quality control measure. Survival and comparative statistical tests, and multivariate regression were performed for the analysis of the variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PRP applied had a platelet concentration factor of 1.9X in respect to blood levels, with no leukocytes or erythrocytes. Thirty\u2010eight patients required surgical intervention after treatment reaching a survival rate of 90.3% with an estimated mean survival time of 54.4\u00a0months. The type of injury (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and the presence of chondropathy were risk factors for surgical intervention after PRP treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.043). All KOOS scores showed a significant statistical increase from baseline to 6\u00a0months (<jats:italic>N<\/jats:italic>\u2009=\u200993) and 18\u00a0months (<jats:italic>N<\/jats:italic>\u2009=\u200966) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The number of cases with minimal clinically important improvement (MCII) at 6\u00a0months and 18\u00a0months post\u2010treatment was 65 (69.9%) and 43 (65.2%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of intrameniscal and intraarticular PRP infiltrations is a valid conservative treatment for meniscal injuries avoiding the need for surgical intervention. Its efficacy is higher in horizontal tears and decreases when joint degeneration is present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-023-07470-4","type":"journal-article","created":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T23:10:48Z","timestamp":1686525048000},"page":"4246-4256","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High survival rate after the combination of intrameniscal and intraarticular infiltrations of platelet\u2010rich plasma as conservative treatment for meniscal lesions"],"prefix":"10.1002","volume":"31","author":[{"given":"Mikel","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Arthroscopic Surgery Unit Hospital Vithas Vitoria Vitoria\u2010Gasteiz Spain"},{"name":"<!--<label>2<\/label>--> Advanced Biological Therapy Unit Hospital Vithas Vitoria C\/Beato Tom\u00e1s de Zum\u00e1rraga 10 01008 Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Jorquera","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Advanced Biological Therapy Unit Hospital Vithas Vitoria C\/Beato Tom\u00e1s de Zum\u00e1rraga 10 01008 Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Miren","family":"Bilbao","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Arthroscopic Surgery Unit Hospital Vithas Vitoria Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00ednza","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--> Advanced Biological Therapy Unit Hospital Vithas Vitoria C\/Beato Tom\u00e1s de Zum\u00e1rraga 10 01008 Vitoria\u2010Gasteiz 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