{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:04:16Z","timestamp":1783976656191,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The role of mesenchymal stem cells (MSC) in supporting the formation of new meniscal tissue in a meniscal scaffold is not well understood. The objective of this study was to assess the quality of the meniscal tissue produced in a fibronectin (FN)\u2010coated polyurethane (PU) meniscal scaffold after a meniscal injury was made in an experimental rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve New Zealand white rabbits were divided in two groups after performing a medial meniscectomy of the anterior horn. In group 1, the meniscal defect was reconstructed with a non\u2010MSC supplemented FN\u2010coated PU scaffold. On the other hand, the same scaffold supplemented with MSCs was used in group 2. The animals were sacrificed at 12 week after index surgery. A modified scoring system was used for histological assessment. This new scoring (ranging from 0 to 15) includes a structural evaluation (meniscal scaffold interface and extracellular matrix production) and tissue quality evaluation (proteoglycan and type I\u2010collagen content).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meniscal scaffold was found loose in the joint in three cases, corresponding to two cases in group 1 and 1 case in group 2. No differences were observed between the groups in terms of the total score (7.0\u2009\u00b1\u20090.9 <jats:italic>vs.<\/jats:italic> 9.4\u2009\u00b1\u20092.6, p\u2009=\u20090.09). However, differences were observed in group 2\u00a0in which 2 out of the 5 scored items, scaffold integration (1\u2009\u00b1\u20090.0 <jats:italic>vs.<\/jats:italic> 1.9\u2009\u00b1\u20090.6, p\u2009=\u20090.03) and proteoglycan production (1.2\u2009\u00b1\u20090.3 <jats:italic>vs.<\/jats:italic> 2.4\u2009\u00b1\u20090.2, p\u2009=\u20090.001). A trend to a higher production of Type I\u2010Collagen production was also observed in group 2 (1.1\u2009\u00b1\u20090.4 <jats:italic>vs.<\/jats:italic> 1.4\u2009\u00b1\u20090.7, p\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a rabbit model at 12 weeks, the adhesion of MSCs to a FN\u2010coated PU scaffold improves scaffold integration, proteoglycan production and the characteristics of the new meniscal\u2010like tissue obtained when compared to a non\u2010supplemented scaffold. This fact could be a major step toward improving the adhesion of the MSCs to meniscal scaffolds and, consequently, the obtention of better quality meniscal tissue.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00167-023-07562-1","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T03:02:37Z","timestamp":1695092557000},"page":"5104-5110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fibronectin\u2010coated polyurethane meniscal scaffolding supplemented with MSCs improves scaffold integration and proteoglycan production in a rabbit model"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-2439","authenticated-orcid":false,"given":"Ra\u00fal","family":"Torres\u2010Claramunt","sequence":"first","affiliation":[{"name":"<!--<label>1<\/label>--> Orthopaedic Department, Hospital del Mar Universitat Aut\u00f2noma Barcelona Passeig Mar\u00edtim de la Barceloneta 25\u201029 08003 Barcelona Spain"},{"name":"<!--<label>2<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/03a8gac78<\/institution-id>--> IMIM (Hospital del Mar Medical Research Institute) C\/Dr. Aiguader 88 08003 Barcelona Spain"},{"name":"<!--<label>3<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/052g8jq94<\/institution-id>--> Orthopaedic Department ICATME\u2010Institut Universitari Quir\u00f3n\u2010Dexeus, Universitat Aut\u00f2noma Barcelona C\/ Sabino de Arana 5\u201019 08028 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-6534","authenticated-orcid":false,"given":"Santos","family":"Mart\u00ednez\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Orthopaedic Department, Hospital del Mar Universitat Aut\u00f2noma Barcelona Passeig Mar\u00edtim de la Barceloneta 25\u201029 08003 Barcelona Spain"},{"name":"<!--<label>2<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/03a8gac78<\/institution-id>--> IMIM (Hospital del Mar Medical Research Institute) C\/Dr. Aiguader 88 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"S\u00e1nchez\u2010Soler","sequence":"additional","affiliation":[{"name":"<!--<label>1<\/label>--> Orthopaedic Department, Hospital del Mar Universitat Aut\u00f2noma Barcelona Passeig Mar\u00edtim de la Barceloneta 25\u201029 08003 Barcelona Spain"},{"name":"<!--<label>2<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/03a8gac78<\/institution-id>--> IMIM (Hospital del Mar Medical Research Institute) C\/Dr. Aiguader 88 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-7381","authenticated-orcid":false,"given":"Laura","family":"Tio\u2010Barrera","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/03a8gac78<\/institution-id>--> IMIM (Hospital del Mar Medical Research Institute) C\/Dr. Aiguader 88 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Arredondo","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--><!--<institution-id institution-id-type=\"ROR\">https:\/\/ror.org\/03a8gac78<\/institution-id>--> IMIM (Hospital del Mar Medical Research Institute) C\/Dr. Aiguader 88 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Triginer","sequence":"additional","affiliation":[{"name":"<!--<label>2<\/label>--><!--<institution-id 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