{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:42:39Z","timestamp":1790754159788,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006470","name":"Aristotle University of Thessaloniki","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006470","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Implantation of mesenchymal stem cells (MSCs) is a potential cell\u2010based modality for cartilage repair. Currently, its clinical use largely surrounds focal cartilage defect repair and intra\u2010articular injections in knee osteoarthritis. The MSCs\u2019 implantation efficacy as a treatment option for osteoarthritis remains contentious. This systematic review aims to evaluate studies that focused on MSCs implantation in patients with knee OA to provide a summary of this treatment option outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was performed in PubMed (Medline), Scopus, Cinahl, and the Cochrane Library. Original studies investigating outcomes of MSCs implantations in patients with knee OA were included. Data on clinical outcomes using subjective scores, radiological outcomes, and second\u2010look arthroscopy gradings were extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies were included in this review. In all included studies, clinical outcome scores revealed significantly improved functionality and better postoperative pain scores at 2\u20133\u00a0years follow\u2010up. Improved cartilage volume and quality at the lesion site was observed in five studies that included a postoperative magnetic resonance imaging assessment and studies that performed second\u2010look arthroscopy. No major complications or tumorigenesis occurred. Outcomes were consistent in both single MSCs implantation and concurrent HTO with MSCs implantation in cases with excessive varus deformity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to the available literature, MSCs implantation in patients with mild to moderate knee osteoarthritis is safe and provides short\u2010term clinical improvement and satisfactory cartilage restoration, either as a standalone procedure or combined with HTO in cases with axial deformity. However, the evidence is limited due to the high heterogeneity among studies and the insufficient number of studies including a control group and mid\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-023-07575-w","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:02:03Z","timestamp":1695380523000},"page":"5306-5318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mesenchymal stem cell implantation provides short\u2010term clinical improvement and satisfactory cartilage restoration in patients with knee osteoarthritis but the evidence is limited: a systematic review performed by the early\u2010osteoarthritis group of ESSKA\u2010European knee associates section"],"prefix":"10.1002","volume":"31","author":[{"given":"Hamid Rahmatullah Bin Abd","family":"Razak","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Sengkang General Hospital 110 Sengkang East Way 544886 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Corona","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Fondazione Policlinico Universitario A. Gemelli IRCCS\u2010Sacred Heart Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-7755","authenticated-orcid":false,"given":"Trifon","family":"Totlis","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Surgical Anatomy School of Medicine Faculty of Health Sciences Aristotle University of Thessaloniki Thessaloniki Greece"},{"name":"Thessaloniki Minimally Invasive Surgery (The\u2010MIS) Orthopaedic Centre St. Luke\u2019s Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Yi Tammy","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore 10\u00a0Medical Drive 117597 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Filipe","family":"Salreta","sequence":"additional","affiliation":[{"name":"Orthopaedic and Traumatology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obeida","family":"Sleiman","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma Surgery and Sports Traumatology Catholic Clinical Center Ruhr North (KKRN) Dorsten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Vasso","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences University of Molise Via Francesco De Sanctis 86100 Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike H.","family":"Baums","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma Surgery and Sports Traumatology Catholic Clinical Center Ruhr North (KKRN) Dorsten 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