{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:33:48Z","timestamp":1787236428349,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate studies utilizing orthobiologics in the management of femoroacetabular impingement syndrome (FAIS) to (1) assess the indications for usage, and (2) analyze patient\u2010reported outcome measures (PROM) following treatment. It was hypothesized that orthobiologics would (1) be utilized for symptomatic FAIS in the setting of labral or chondral pathology, and (2) improve PROM at most recent follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Pubmed, Ovid Medline, Cochrane, and Web of Science databases were searched for clinical studies evaluating orthobiologics [hyaluronic acid (HA), platelet\u2010rich plasma (PRP), or cell\u2010based therapy (CBT) for treatment of FAIS. Exclusion criteria included orthobiologics used in conjunction with cartilage transfer or scaffolding procedures and a primary indication other than FAIS. Data collection included patient demographics, indications, and baseline and most recent PROM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies (one level I, four level II, four level III, and two level IV evidence) met inclusion criteria, consisting of 440 patients with mean ages ranging from 32.8 to 47\u00a0years. All 11 studies demonstrated an improvement in PROM from baseline to most\u2010recent follow\u2010up. Four studies administered PRP either intraoperatively or the day after surgery as an adjunct to labral repair. CBT was used intraoperatively in the setting of acetabular chondral lesions (three studies) and labral repair (one study). When comparing to a control group at most recent follow\u2010up, three PRP cohorts demonstrated similar PROM (n.s.), while one PRP group exhibited worse visual analog pain scores (2.5 vs. 3.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and modified Harris Hip Scores (mHHS) (82.6 vs. 78.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). The four CBT studies reported favorable results compared to a control group, with a significantly higher mHHS at most recent follow\u2010up or mean improvement from baseline in Hip Outcome Score\u2013Activities of Daily Living (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Three studies reported on HA, which was utilized exclusively in the nonoperative setting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative PRP and CBT have been commonly reported in the setting of hip arthroscopy for labral repairs and acetabular chondral lesions, respectively. The CBT cohorts demonstrated more favorable PROM at most recent follow\u2010up when compared to a control group, though these results should be interpreted with caution due to heterogeneity of orthobiologic preparations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00167-023-07624-4","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:02:22Z","timestamp":1698746542000},"page":"6020-6038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Orthobiologics as an adjunct in treatment of femoroacetabular impingement syndrome: cell\u2010based therapies facilitate improved postoperative outcomes in the setting of acetabular chondral lesions\u2014a systematic review"],"prefix":"10.1002","volume":"31","author":[{"given":"Tracy","family":"George","sequence":"first","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Curley","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheema K.","family":"Saeed","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Kuhns","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Parsa","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-8647","authenticated-orcid":false,"given":"Benjamin G.","family":"Domb","sequence":"additional","affiliation":[{"name":"American Hip Institute Research Foundation 60018 Chicago IL USA"},{"name":"American Hip Institute 60018 Chicago IL USA"},{"name":"999 E Touhy Ave, Suite 450 60018 Des Plaines IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2581-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0b013e3182999740"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.05.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517749919"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201402000-00002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19415"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-020-02388-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.11.073"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516665809"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.06.033"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517741169"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.04.148"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.10.125"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhps\/hnab001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509349921"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0060-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000096804.78689.c2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102179"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31202-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2023.01.017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.08.032"},{"issue":"12","key":"e_1_2_10_24_1","first-page":"69","article-title":"Micro\u2010fragmented Adipose Tissue Transplantation (MATT) for the treatment of acetabular delamination. 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December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"B.G.D has received royalties from Arthrex, Inc., DJO Global, Inc., Medacta USA, Inc., Orthomerica; has received speaking fees from Arthrex, Inc., Stryker Corp, Medacta Inc; has received consulting fees from Arthrex, Inc; has received research support from Arthrex, Inc., Ossur, Stryker Endoscopy, and Medacta Inc; has received any other financial or material support from Arthrex, Inc., Stryker Endoscopy. B.G.D serves on the editorial or governing board for Arthroscopy, a board member for the Arthroscopy Journal, American Hip Institute Research Foundation, AANA Learning Center Committee. The American Hip Institute Research Foundation fund research and is where our study was performed. B.D.K is a member of the Arthroscopy Editorial Board. Ms. George, Dr. Curley, Ms. Saeed, and Dr. Parsa have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the ethical standards in the 1964 Declaration of Helsinki. This study was carried out in accordance with relevant regulations of the US Health Insurance Portability and Accountability Act (HIPAA). Details that might disclose the identity of the subjects under study have been omitted. This study was approved by the IRB. (IRB ID: 5276).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}